BPG is committed to discovery and dissemination of knowledge
Featured Articles
4/8/2026 9:56:22 AM | Browse: 112 | Download: 320
 |
Received |
|
2025-11-13 05:13 |
|
Peer-Review Started |
|
2025-11-13 05:13 |
|
First Decision by Editorial Office Director |
|
2025-12-31 07:40 |
|
Return for Revision |
|
2025-12-31 07:40 |
|
Revised |
|
2026-01-09 09:16 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-01-23 02:39 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-01-23 08:37 |
|
Articles in Press |
|
2026-01-23 08:37 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-03-27 08:41 |
|
Publish the Manuscript Online |
|
2026-04-08 07:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Digital polymerase chain reaction detection of telomerase reverse transcriptase promoter mutations in hepatitis B virus related hepatocellular carcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Shuai Shao, Yu Xiong, Mo-Wei Kong, Yang Yu and Chun-Xiang Zhang |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Chun-Xiang Zhang, MD, PhD, Professor, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, No. 25 Taiping Street, Luzhou 646000, Sichuan Province, China. zhangchx999@163.com |
| Key Words |
Telomerase reverse transcriptase promoter mutation; Digital polymerase chain reaction; Hepatitis B virus; Hepatocellular carcinoma; Telomerase activation; Prognostic biomarker; Liquid biopsy |
| Core Tip |
This study provides the first systematic evidence that an optimized digital polymerase chain reaction assay can achieve ultra-sensitive detection of the guanine-cytosine-rich telomerase reverse transcriptase (TERT) promoter C228T mutation in hepatitis B virus-related hepatocellular carcinoma, with 100% sensitivity and a detection limit of 0.55 cp/μL - far surpassing traditional sequencing methods. By integrating TERT mutation status with clinical variables, we developed a prognostic nomogram that accurately predicts overall and disease-free survival, enabling early recurrence detection through ctDNA-based liquid biopsy. This work bridges molecular mechanism and clinical translation, establishing TERT mutation detection by digital polymerase chain reaction as a cornerstone technology for precision hepatocarcinology and individualized postoperative surveillance. |
| Publish Date |
2026-04-08 07:28 |
| Citation |
Shao S, Xiong Y, Kong MW, Yu Y, Zhang CX. Digital polymerase chain reaction detection of telomerase reverse transcriptase promoter mutations in hepatitis B virus related hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(4): 116504
|
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i4/116504.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i4.116504 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
