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5/14/2026 9:40:47 AM | Browse: 19 | Download: 38
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Received |
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2025-11-17 04:35 |
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Peer-Review Started |
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2025-11-17 04:35 |
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First Decision by Editorial Office Director |
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2025-11-28 07:08 |
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Return for Revision |
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2025-11-28 07:08 |
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Revised |
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2025-12-12 23:07 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-06 02:50 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-06 11:46 |
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Articles in Press |
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2026-02-06 11:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-23 08:21 |
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Publish the Manuscript Online |
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2026-05-14 09:17 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Paola B Da Silva, Laís Lopes-Bute, Janaína Fischer, Ana P Parcianello, Renata Pires-Duarte, Rafael M Luiz, Ana P C Brandalize, Fabrício F Melo, Cinthia F Wendel, Kádima N Teixeira and Ana C Zarpelon-Schutz |
| Funding Agency and Grant Number |
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| Corresponding Author |
Ana C Zarpelon-Schutz, PhD, Pós-graduação em Bioquímica Biologia Molecular, Universidade Federal do Paraná - Setor Palotina, Max Planck, 3796, Palotina 85950-000, Paraná, Brazil. ana.zarpelon@ufpr.br |
| Key Words |
Antinociceptive activity; Anti-inflammatory activity; Butia capitata; Colorectal cancer; Cyclooxygenase-2; Phenolic compounds; Ulcerative colitis |
| Core Tip |
The hydroalcoholic extract of Butia capitata showed antinociceptive activity in mice, in models of pain and/or hyperalgesia caused by acetic acid, formalin, and carrageenan, with an emphasis on reducing the histological damage and the pain symptoms caused by acetic acid-induced acute colitis. The in silico results indicate the potential of phenolic compounds of the extract to inhibit cellular pathways and receptors involved in inflammatory processes, as well as reduce the activation of pathways that promote genetic damage and tumorigenesis. |
| Publish Date |
2026-05-14 09:17 |
| Citation |
Da Silva PB, Lopes-Bute L, Fischer J, Parcianello AP, Pires-Duarte R, Luiz RM, Brandalize APC, Melo FF, Wendel CF, Teixeira KN, Zarpelon-Schutz AC. Protective effects of Butia capitata extract against colitis-driven colorectal tumorigenesis: Insights into its anti-inflammatory and antinociceptive activities. World J Gastrointest Oncol 2026; 18(5): 116568 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i5/116568.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i5.116568 |
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