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7/17/2026 9:49:18 AM | Browse: 8 | Download: 12
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Received |
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2025-11-17 02:33 |
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Peer-Review Started |
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2025-11-17 02:33 |
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First Decision by Editorial Office Director |
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2025-12-30 07:37 |
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Return for Revision |
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2025-12-30 07:37 |
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Revised |
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2025-12-30 09:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-29 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-29 07:20 |
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Articles in Press |
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2026-01-29 07:20 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-07-13 01:07 |
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Publish the Manuscript Online |
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2026-07-17 08:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Editorial |
| Article Title |
Small tumors, big decisions: Rethinking resection and ablation in early hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Marcello Maestri and Ottavia Cicerone |
| Funding Agency and Grant Number |
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| Corresponding Author |
Marcello Maestri, MD, PhD, Professor, General Surgery Unit I - Liver Service, Fondazione IRCCS Policlinico San Matteo, P.le Golgi 19, Pavia 27100, Italy. m.maestri@smatteo.pv.it |
| Key Words |
Hepatocellular carcinoma; Liver resection; Radiofrequency ablation; Therapeutic hierarchy; Barcelona Clinic Liver Cancer; Local ablation |
| Core Tip |
Early hepatocellular carcinoma (HCC) is typically managed with resection or local ablation, yet growing evidence shows that resection provides superior long-term oncologic outcomes whenever feasible. Modern ablative technologies—no-touch RFA, microwave ablation, and fusion-imaging guidance—have improved local control but do not surpass the curative potential of anatomical resection. The limitations of the BCLC staging system highlight the need for individualized decision-making. The therapeutic hierarchy, ranking treatments by intrinsic curative power, offers a dynamic, patient-centered framework better aligned with contemporary practice. Selecting the highest feasible therapy for each patient ensures the best outcomes in early-stage HCC. |
| Publish Date |
2026-07-17 08:23 |
| Citation |
Maestri M, Cicerone O. Small tumors, big decisions: Rethinking resection and ablation in early hepatocellular carcinoma. World J Gastroenterol 2026; 32(29): 116653
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i29/116653.htm |
| DOI |
https://doi.org/10.3748/wjg.116653 |
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