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4/10/2026 8:06:21 AM | Browse: 20 | Download: 46
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Received |
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2025-11-25 04:01 |
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Peer-Review Started |
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2025-11-25 04:01 |
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First Decision by Editorial Office Director |
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2025-12-17 09:02 |
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Return for Revision |
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2025-12-17 09:02 |
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Revised |
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2025-12-23 06:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-09 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-09 08:02 |
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Articles in Press |
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2026-02-09 08:02 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-01 01:16 |
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Publish the Manuscript Online |
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2026-04-10 07:08 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Comparative outcomes of intra-articular, subchondral, and combined injections of peripheral blood mesenchymal stromal cells in knee osteoarthritis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Harish V K Ratna, Naveen Jeyaraman, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman |
| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nādu, India. madhanjeyaraman@gmail.com |
| Key Words |
Osteoarthritis; Peripheral blood; Peripheral blood-derived mesenchymal stromal cells; Regenerative therapy; Cartilage Regeneration; Randomized controlled trial |
| Core Tip |
Optimizing delivery routes for peripheral blood-derived mesenchymal stromal cells is key to enhancing regenerative outcomes in early-grade knee osteoarthritis. This trial compares intra-articular, subchondral, and combined injection techniques using clinical scores and advanced imaging over 12 months. The goal is to establish minimally invasive, evidence-based protocols that improve function, reduce pain, and delay progression - aligned with the Indian healthcare context and regenerative medicine advancements. |
| Publish Date |
2026-04-10 07:08 |
| Citation |
Ratna HVK, Jeyaraman N, Nallakumarasamy A, Muthu S, Jeyaraman M. Comparative outcomes of intra-articular, subchondral, and combined injections of peripheral blood mesenchymal stromal cells in knee osteoarthritis. World J Orthop 2026; 17(4): 116916 |
| URL |
https://www.wjgnet.com/2218-5836/full/v17/i4/116916.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v17.i4.116916 |
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