| ISSN |
1949-8470 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Prospective Study |
| Article Title |
Role of cerebral blood flow changes in post-transjugular intrahepatic portosystemic shunts hepatic encephalopathy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Li Zhuang, Shang-Wen Xu, Jian Fang, Zhi-Qiang Zhang, Shi-An Zhang, Jie-Long Wang, Jiao-Long Zheng, Xiao-Yang Wang and Dong-Liang Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guiding Projects of Social Development of Fujian Province |
2021Y0062 |
| Natural Science Foundation of Fujian Province of China |
2024J011172 |
|
| Corresponding Author |
Dong-Liang Li, MD, PhD, Professor, Department of Hepatobiliary Disease, The 900th Hospital of PLA Joint Logistic Support Force, No. 156 West Second Ring Road North, Fuzhou 350025, Fujian Province, China. dongliangli93@163.com |
| Key Words |
Hepatic encephalopathy; Transjugular intrahepatic portosystemic shunt; Cerebral blood flow; Arterial spin labeling; Resting-state functional magnetic resonance imaging |
| Core Tip |
Using three-dimensional arterial spin labeling and resting-state functional magnetic resonance imaging, we dynamically evaluated cerebral blood flow and spontaneous brain activity in cirrhotic patients undergoing (transjugular intrahepatic portosystemic shunts) TIPS. We demonstrated region-specific cerebral blood flow and amplitude of low-frequency fluctuation alterations after TIPS that correlated with changes in Child-Pugh score, portal pressure gradient and neuropsychological performance. These findings indicate that postoperative cerebral hemodynamic changes, together with hyperammonemia, may contribute to hepatic encephalopathy and that resting-state functional magnetic resonance imaging is a sensitive tool for detecting early or mild cognitive impairment after TIPS. |
| Publish Date |
2026-02-25 05:32 |
| Citation |
Zhuang WL, Xu SW, Fang J, Zhang ZQ, Zhang SA, Wang JL, Zheng JL, Wang XY, Li DL. Role of cerebral blood flow changes in post-transjugular intrahepatic portosystemic shunts hepatic encephalopathy. World J Radiol 2026; 18(2): 116973 |
| URL |
https://www.wjgnet.com/1949-8470/full/v18/i2/116973.htm |
| DOI |
https://dx.doi.org/10.4329/wjr.v18.i2.116973 |
