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7/14/2026 7:36:05 AM | Browse: 13 | Download: 11
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Received |
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2025-12-03 00:57 |
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Peer-Review Started |
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2025-12-03 00:57 |
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First Decision by Editorial Office Director |
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2025-12-16 10:05 |
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2025-12-16 10:05 |
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Revised |
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2025-12-23 20:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-10 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-10 11:53 |
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Articles in Press |
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2026-02-10 11:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-23 00:17 |
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Publish the Manuscript Online |
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2026-07-14 07:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Correspondence |
| Article Title |
Letter to the Editor: Tumor necrosis factor-α signaling and β-cell apoptosis in acute pancreatitis - integrating molecular mechanisms and metabolic implications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Lara Lizzi and Mara Massimi |
| Funding Agency and Grant Number |
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| Corresponding Author |
Mara Massimi, Associate Professor, PhD, Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, L'Aquila 67100, AQ, Italy. mara.massimi@univaq.it |
| Key Words |
Tumor necrosis factor-α; β-cell apoptosis; Oxidative stress; Endoplasmic reticulum stress; Glucose metabolism; Acute pancreatitis; Post-pancreatitis diabetes mellitus; Inflammatory signaling |
| Core Tip |
Tumor necrosis factor-α (TNF-α) contributes to dysglycemia after acute pancreatitis not only by activating apoptotic pathways, but also by coordinating a broader network of inflammatory, oxidative, endoplasmic reticulum stress, and metabolic signals that impair β-cell function. Recognizing TNF-α as an upstream integrator, rather than a single apoptotic trigger, helps explain the heterogeneity of post-pancreatitis dysglycemia and highlights new therapeutic opportunities aimed at enhancing β-cell metabolic resilience. |
| Publish Date |
2026-07-14 07:33 |
| Citation |
Lizzi L, Massimi M. Letter to the Editor: Tumor necrosis factor-α signaling and β-cell apoptosis in acute pancreatitis - integrating molecular mechanisms and metabolic implications. World J Gastroenterol 2026; 32(27): 117268
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i27/117268.htm |
| DOI |
https://doi.org/10.3748/wjg.117268 |
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