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4/20/2026 9:03:30 AM | Browse: 126 | Download: 246
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Received |
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2025-12-08 02:34 |
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Peer-Review Started |
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2025-12-08 02:34 |
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First Decision by Editorial Office Director |
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2026-01-14 08:33 |
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Return for Revision |
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2026-01-14 08:33 |
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Revised |
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2026-01-25 06:15 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-25 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-25 08:11 |
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Articles in Press |
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2026-02-25 08:11 |
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Edit the Manuscript by Language Editor |
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2026-03-01 19:49 |
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Typeset the Manuscript |
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2026-04-07 09:26 |
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Publish the Manuscript Online |
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2026-04-20 08:05 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Opinion Review |
| Article Title |
Adipose-derived mesenchymal stem cells: Source-dependent heterogeneity, translational challenges, and emerging precision strategies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Qing Xu, Huan Li, Jian-Chuan Deng and Nan Zhang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jian-Chuan Deng, Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University, No. 288 Tianwen Avenue, Nan’an District, Chongqing 400010, China. dengjccq@hospital.cqmu.edu.cn |
| Key Words |
Adipose-derived mesenchymal stem cells; Source dependency; Donor heterogeneity; Adipose tissue depot; Secretome; Regenerative medicine |
| Core Tip |
Adipose-derived mesenchymal stem cells are a heterogeneous cell population whose biological and therapeutic properties are strongly influenced by donor background, adipose tissue origin, and manufacturing conditions. This review summarizes source-dependent differences in proliferation, differentiation, immunomodulation, and secretome composition, and highlights key challenges in standardization and clinical translation. Emerging approaches, including single-cell profiling, multi-omics analysis, and cell-free secretome-based therapy, may improve the precision and reproducibility of adipose-derived mesenchymal stem cell-based regenerative strategies. |
| Publish Date |
2026-04-20 08:05 |
| Citation |
Xu Q, Li H, Deng JC, Zhang N. Adipose-derived mesenchymal stem cells: Source-dependent heterogeneity, translational challenges, and emerging precision strategies. World J Stem Cells 2026; 18(4): 117414
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| URL |
https://www.wjgnet.com/1948-0210/full/v18/i4/117414.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i4.117414 |
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