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4/24/2026 5:54:48 AM | Browse: 23 | Download: 54
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Received |
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2025-12-10 00:40 |
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Peer-Review Started |
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2025-12-10 00:40 |
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First Decision by Editorial Office Director |
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2025-12-30 07:51 |
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Return for Revision |
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2025-12-30 07:51 |
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Revised |
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2026-01-01 01:58 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-12 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-12 23:38 |
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Articles in Press |
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2026-02-12 23:38 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-15 02:09 |
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Publish the Manuscript Online |
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2026-04-24 05:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Helicobacter pylori eradication and the prevention of peptic ulcer bleeding and cardiovascular disease progression in chronic aspirin users
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Atteyat A Semeya, Wael Ahmed Makled, Mohamed A Elnagdy, Rasha Elgamal and Amira A A Othman |
| Funding Agency and Grant Number |
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| Corresponding Author |
Amira A A Othman, Lecturer, MD, PhD, Principal Investigator, Department of Internal Medicine, Suez University, Cairo-Suez Road, Suez 43511, Suez, Egypt. amira.othman@med.suezuni.edu.eg |
| Key Words |
Helicobacter pylori; Peptic ulcer bleeding; Low-dose aspirin; Eradication therapy; Gastroprotection |
| Core Tip |
This prospective observational study shows that persistent Helicobacter pylori infection markedly increases the risk of peptic ulcer bleeding and cardiovascular (CV) disease progression in long-term low-dose aspirin users. Successful eradication lowered ulcer bleeding rates from 11.9% to 3.7% - an approximately 69% relative risk reduction- and was associated with significantly fewer CV events. These findings support routine Helicobacter pylori screening and eradication as a practical strategy to improve both gastrointestinal safety and CV outcomes in high-risk aspirin users. |
| Publish Date |
2026-04-24 05:43 |
| Citation |
Semeya AA, Makled WA, Elnagdy MA, Elgamal R, Othman AAA. Helicobacter pylori eradication and the prevention of peptic ulcer bleeding and cardiovascular disease progression in chronic aspirin users. World J Gastroenterol 2026; 32(17): 117544 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i17/117544.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i17.117544 |
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