| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Characteristics and prognosis of primary gastric adenosquamous carcinoma: A multicenter retrospective study based on propensity score matching
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Wen Chen, Zhong-Yi Dong, Xin-Xin Wang, Yi Cao, Jian-Xian Lin, Hao Chen, Hao-Yu Zhang, Yong-Biao Xiao, Guo-Xin Li, Zheng-Rong Li, Lin Chen, Xiang Xia and Zi-Zhen Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Commission of Shanghai Municipality |
No. 25SF1905600 |
| National Natural Science Foundation of China |
No. 82303428 |
| National Natural Science Foundation of China |
No. 82473077 |
| National Natural Science Foundation of China |
No. 82473065 |
|
| Corresponding Author |
Zi-Zhen Zhang, MD, PhD, Professor, Department of Gastrointestinal Surgery, School of Medicine, Shanghai Jiao Tong University, No. 160 Pu Jian Road, Shanghai 200127, China. zhangzizhen@renji.com |
| Key Words |
Stomach neoplasms; Adenocarcinoma; Adjuvant chemotherapy; Programmed cell death-ligand 1; Immunotherapy; Survival analysis |
| Core Tip |
This multicenter retrospective study represents the largest Eastern cohort of patients with primary gastric adenosquamous carcinoma (PGASC). Applying propensity score matching to patients with gastric adenocarcinoma to investigate PGASC we found that PGASC was associated with worse prognosis. No survival benefit was observed for standard adjuvant chemotherapy in locally advanced cases. However, increased programmed cell death-ligand 1 expression was observed in PGASC tissues, indicating that immunotherapy could represent a promising novel therapeutic strategy for this aggressive malignancy. |
| Publish Date |
2026-05-14 09:17 |
| Citation |
Chen YW, Dong ZY, Wang XX, Cao Y, Lin JX, Chen H, Zhang HY, Xiao YB, Li GX, Li ZR, Chen L, Xia X, Zhang ZZ. Characteristics and prognosis of primary gastric adenosquamous carcinoma: A multicenter retrospective study based on propensity score matching. World J Gastrointest Oncol 2026; 18(5): 117580 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i5/117580.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i5.117580 |
