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5/11/2026 9:13:23 AM | Browse: 22 | Download: 46
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Received |
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2025-12-16 03:42 |
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Peer-Review Started |
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2025-12-18 00:04 |
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First Decision by Editorial Office Director |
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2026-01-06 06:14 |
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Return for Revision |
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2026-01-06 06:14 |
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Revised |
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2026-01-08 09:30 |
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Publication Fee Transferred |
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2026-01-10 02:25 |
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Second Decision by Editor |
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2026-02-06 02:59 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-24 06:56 |
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Articles in Press |
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2026-02-24 06:56 |
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Edit the Manuscript by Language Editor |
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2026-02-28 22:09 |
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Typeset the Manuscript |
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2026-04-28 10:09 |
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Publish the Manuscript Online |
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2026-05-11 09:00 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Zuo Gui Pill alleviates M1 macrophage polarization in type 2 diabetic osteoporosis through the Nrf2/HO-1/XCT/GPX4 pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi Zhao, Xiu-Zhi Feng, Wen-Qi Cao, Yi-Ran Chen, Ying Yang, Jing-Chi Liu, Ao Xu, Yan-Ling Ren and Zhi-Min Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82174260 |
| Liaoning Provincial Department of Science and Technology Joint Fund for Doctoral Research Initiation Project |
No. 2023-BSBA-224 |
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| Corresponding Author |
Yan-Ling Ren, Professor, Liaoning University of Traditional Chinese Medicine Affiliated Hospital, No. 79 Chongshandong Road, Shenyang 110847, Liaoning Province, China. lnutcmren@163.com |
| Key Words |
Zuo Gui Pill; Type 2 diabetes osteoporosis; Bone marrow macrophage; Oxidative stress; Ferroptosis |
| Core Tip |
Regulate the M1 polarization of bone marrow macrophages in type 2 diabetic osteoporosis treatment by activating the nuclear factor E2-related factor 2/hemoxygenase-1/XCT/glutathione peroxidase 4 signaling pathway. Zuo Gui Pill, metformin, and Fer-1 can work synergistically to restore nuclear factor E2-related factor 2, upregulate hemoxygenase-1, and inhibit M1 polarization of bone marrow macrophages. |
| Publish Date |
2026-05-11 09:00 |
| Citation |
Zhao Y, Feng XZ, Cao WQ, Chen YR, Yang Y, Liu JC, Xu A, Ren YL, Wang ZM. Zuo Gui Pill alleviates M1 macrophage polarization in type 2 diabetic osteoporosis through the Nrf2/HO-1/XCT/GPX4 pathway. World J Diabetes 2026; 17(5): 117635 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i5/117635.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i5.117635 |
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