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5/13/2026 9:09:34 AM | Browse: 21 | Download: 30
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Received |
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2025-12-17 01:17 |
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Peer-Review Started |
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2025-12-17 01:17 |
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First Decision by Editorial Office Director |
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2025-12-31 08:22 |
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Return for Revision |
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2025-12-31 08:22 |
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Revised |
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2025-12-31 12:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-09 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-09 05:08 |
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Articles in Press |
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2026-02-09 05:08 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-16 09:43 |
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Publish the Manuscript Online |
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2026-05-13 08:18 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Review |
| Article Title |
Early-life gastrointestinal inflammation and the developing brain: Unravelling the pathways to long-term cognitive dysfunction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mohammed Al-Beltagi, Nermin Kamal Saeed, Yasser El-Sawaf, Adel Salah Bediwy and Reem Elbeltagi |
| Funding Agency and Grant Number |
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| Corresponding Author |
Mohammed Al-Beltagi, Chairman, Consultant, Head, MD, PhD, Professor, Department of Pediatrics, Faculty of Medicine, Tanta University, 1 Hassan Radwan Street, Tanta 31511, Algharbia, Egypt. mbelrem@hotmail.com |
| Key Words |
Gut-brain axis; Neurodevelopment; Necrotizing enterocolitis; Inflammatory bowel disease; Celiac disease; Cognitive dysfunction; Microbiome |
| Core Tip |
Early-life and chronic gastrointestinal inflammation (e.g., necrotizing enterocolitis, inflammatory bowel disease, celiac disease) must be recognized as critical red flags for long-term neurocognitive and psychiatric dysfunction. These outcomes, including impaired executive function, attention deficits, and mood disorders, are driven by sustained systemic inflammation, the Kynurenine pathway, and micronutrient deficiencies. Clinical practice requires a neuroprotective strategy that integrates gastrointestinal specialists with neurodevelopmental and mental health screening protocols. Therapeutic goals should prioritize achieving deep mucosal healing and correcting nutritional deficits (iron, B-vitamins, omega-3s) to mitigate brain risk and improve long-term functional capacity. Future research must validate these interventions to solidify the therapeutic potential of the gut-brain axis. |
| Publish Date |
2026-05-13 08:18 |
| Citation |
Al-Beltagi M, Saeed NK, El-Sawaf Y, Bediwy AS, Elbeltagi R. Early-life gastrointestinal inflammation and the developing brain: Unravelling the pathways to long-term cognitive dysfunction. World J Clin Pediatr 2026; 15(2): 117843 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i2/117843.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i2.117843 |
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