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3/24/2026 6:36:04 AM | Browse: 108 | Download: 149
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Received |
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2025-12-28 08:40 |
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2025-12-28 08:40 |
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2026-01-12 08:36 |
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2026-01-12 08:36 |
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2026-02-01 13:51 |
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2026-03-05 02:42 |
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2026-03-05 06:12 |
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Articles in Press |
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2026-03-05 06:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-03-17 02:53 |
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2026-03-24 06:27 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© Author(s) (or their employer(s)) 2026. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Immunoglobulin replacement therapy and infection risk in chronic lymphocytic leukemia: A systematic review and meta-analysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tsampika-Vasileia Kalamara, Konstantinos Dodos and Vasiliki E Georgakopoulou |
| Funding Agency and Grant Number |
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| Corresponding Author |
Vasiliki E Georgakopoulou, MD, Department of Pathophysiology, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, 17 Agiou Toma Street, Athens 11527, Greece. vaso_georgakopoulou@hotmail.com |
| Key Words |
Chronic lymphocytic leukemia; Immunoglobulin replacement therapy; Infection prevention; Hypogammaglobulinemia; Meta-analysis |
| Core Tip |
Immunoglobulin replacement therapy (IgRT) is widely used to prevent infections in patients with chronic lymphocytic leukemia, yet its clinical benefit remains controversial. By applying a dual analytical approach that distinguishes between first infection risk and recurrent infection burden, this meta-analysis demonstrates that IgRT reduces the likelihood of experiencing at least one infection but does not prevent, and may even increase, recurrent infection rates. These findings support a selective, risk-stratified use of IgRT in chronic lymphocytic leukemia rather than routine administration and highlight the need for standardized infection reporting and contemporary trials alongside modern targeted therapies. |
| Publish Date |
2026-03-24 06:27 |
| Citation |
Kalamara TV, Dodos K, Georgakopoulou VE. Immunoglobulin replacement therapy and infection risk in chronic lymphocytic leukemia: A systematic review and meta-analysis. World J Clin Cases 2026; 14(9): 118210 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i9/118210.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i9.118210 |
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