| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Beyond glycemic control: How semaglutide reshapes intestinal neuroception via transforming growth factor-β/brain-derived neurotrophic factor signaling hubs
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Hao-Yao Pan, Jia-Xin Liang, Wei-Wei Chen, Yi-Yang Sheng, Wen-Jing Zhang, Xue-Wen Zhu, Shuai-Yan Wang, Guan-Hu Yang, Bin Xu and Tian-Cheng Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82305376 |
| the Young Talent Support Program of the China Association for Acupuncture-Moxibustion |
2024-2026ZGZJXH-QNRC005 |
| the 2024 Jiangsu Provincial Young Scientific and Technological Talent Support Program |
JSTJ-2024-380 |
| Talent Cultivation Program for Young Researchers, Key Laboratory of the Ministry of Education Project |
zyqt202501, zyqt202503 |
|
| Corresponding Author |
Tian-Cheng Xu, Academic Fellow, CEO, Chairman, Consultant, Full Professor, Head, MD, PhD, President, Professor, Visiting Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Glucagon-like peptide-1 receptor agonist; Semaglutide; Transforming growth factor β; Brain-derived neurotrophic factor; Transient receptor potential vanilloid 1; Gut-brain axis |
| Core Tip |
Semaglutide,a leading glucagon-like peptide-1 receptor agonist, reshapes gut-brain communication by bidirectionally modulating the transforming growth factor-β/brain-derived neurotrophic factor signaling axis in the gut. It promotes neuroprotective brain-derived neurotrophic factor via phosphatidylinositol 3-kinase/protein kinase B/cyclic adenosine monophosphate-response element-binding protein while suppressing profibrotic transforming growth factor-β/Smad signaling. Combined with beneficial shifts in gut microbiota and anti-inflammatory effects, this action remodels enteric neural perception, extending its therapeutic potential beyond metabolism to neuropsychiatric and neurodegenerative disorders. |
| Publish Date |
2026-03-24 06:27 |
| Citation |
Pan HY, Liang JX, Chen WW, Sheng YY, Zhang WJ, Zhu XW, Wang SY, Yang GH, Xu B, Xu TC. Beyond glycemic control: How semaglutide reshapes intestinal neuroception via transforming growth factor-β/brain-derived neurotrophic factor signaling hubs. World J Clin Cases 2026; 14(9): 118295 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i9/118295.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i9.118295 |
