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3/16/2026 10:09:54 AM | Browse: 16 | Download: 20
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Received |
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2026-01-02 13:40 |
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Peer-Review Started |
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2026-01-02 13:45 |
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First Decision by Editorial Office Director |
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2026-01-16 06:42 |
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Return for Revision |
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2026-01-16 06:42 |
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Revised |
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2026-01-20 04:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-02-10 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-10 07:22 |
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Articles in Press |
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2026-02-10 07:22 |
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Edit the Manuscript by Language Editor |
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2026-02-13 22:10 |
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Typeset the Manuscript |
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2026-03-06 03:45 |
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Publish the Manuscript Online |
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2026-03-16 09:13 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Clinical Neurology |
| Manuscript Type |
Minireviews |
| Article Title |
Temporal Lobe Epilepsy as a Model of Accelerated Brain Aging: Roles of Biological Aging Markers and miRNA Dysregulation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rekha Dwivedi, Rashmi Gupta, Monika Pahuja, Jasmine Parihar, Manjari Tripathi, Rima Dada and Prabhakar Tiwari |
| Funding Agency and Grant Number |
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| Corresponding Author |
Prabhakar Tiwari, PhD, Senior Researcher, Department of Anatomy, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, Delhi, India. prabhakt@gmail.com |
| Key Words |
Temporal lobe epilepsy, Biological aging markers; Epigenetics; MicroRNAs; Epileptogenesis |
| Core Tip |
Core Tip: Temporal lobe epilepsy (TLE) is traditionally viewed as a seizure disorder, but evidence indicates it is a progressive condition resembling accelerated brain aging. Patients with chronic TLE show early cognitive decline, hippocampal atrophy, neuroinflammation, and neurodegenerative changes beyond age expectations. This mini-review highlights key aging hallmarks in TLE including oxidative stress, mitochondrial dysfunction, chronic inflammation (“inflammaging”), impaired proteostasis, and autophagy dysregulation—and emphasizes microRNAs (miRNAs) as epigenetic regulators linking epileptogenesis to neuronal aging. Understanding these mechanisms may aid biomarker development and inspire disease-modifying therapeutic strategies beyond seizure control. |
| Publish Date |
2026-03-16 09:13 |
| Citation |
Dwivedi R, Gupta R, Pahuja M, Parihar J, Tripathi M, Dada R, Tiwari P. Temporal Lobe Epilepsy as a Model of Accelerated Brain Aging: Roles of Biological Aging Markers and miRNA Dysregulation. World J Clin Cases 2026; 14(8): 118420 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i8/118420.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i8.118420 |
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