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3/16/2026 10:09:54 AM | Browse: 19 | Download: 21
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Received |
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2026-01-06 07:15 |
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Peer-Review Started |
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2026-01-06 07:15 |
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First Decision by Editorial Office Director |
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2026-01-14 07:57 |
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2026-01-14 07:57 |
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Revised |
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2026-01-21 04:02 |
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Second Decision by Editor |
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2026-02-04 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-02-04 04:03 |
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Articles in Press |
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2026-02-04 04:03 |
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Edit the Manuscript by Language Editor |
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2026-02-13 22:13 |
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Typeset the Manuscript |
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2026-03-06 03:47 |
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Publish the Manuscript Online |
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2026-03-16 09:13 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Combination of N-methyl-D-aspartate receptor antagonists and propofol for procedural sedation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Muhammad Shaheer Bin Faheem, Syed Tawassul Hassan, Faheem Feroze, Ayesha Khan, Syeda Umbreen Munir, Ali Khaliq, Syeda Takreem Fatima, Roni Mendonca and Salim Surani |
| Funding Agency and Grant Number |
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| Corresponding Author |
Salim Surani, FACP, FCCP, MD, Professor, Department of Medicine, University of Houston, 4302 University Drive, TX, 77004, United States. srsurani@hotmail.com |
| Key Words |
N-methyl-D-aspartate receptor antagonists; Ketamine; Esketamine; Propofol; Procedural sedation |
| Core Tip |
This meta-analysis of nineteen randomized controlled trials evaluates the safety and efficacy of combining N-methyl-D-aspartate receptor antagonists, specifically ketamine and esketamine, with propofol for procedural sedation. Our pooled analysis demonstrates that this combination significantly reduces the risk of hypotension and the need for respiratory interventions compared to propofol monotherapy. However, clinicians must remain vigilant regarding the increased risk of transient hallucinations. These findings support the use of Ketofol and esketamine-propofol as valuable, hemodynamically stable alternatives for sedation in diverse clinical settings. |
| Publish Date |
2026-03-16 09:13 |
| Citation |
Faheem MSB, Hassan ST, Feroze F, Khan A, Munir SU, Khaliq A, Fatima ST, Mendonca R, Surani S. Combination of N-methyl-D-aspartate receptor antagonists and propofol for procedural sedation. World J Clin Cases 2026; 14(8): 118582 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i8/118582.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i8.118582 |
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