BPG is committed to discovery and dissemination of knowledge
Featured Articles
5/11/2026 9:13:23 AM | Browse: 19 | Download: 35
 |
Received |
|
2026-01-12 01:29 |
|
Peer-Review Started |
|
2026-01-22 00:41 |
|
First Decision by Editorial Office Director |
|
2026-02-06 09:32 |
|
Return for Revision |
|
2026-02-06 09:32 |
|
Revised |
|
2026-02-13 01:28 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2026-03-09 02:54 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-03-17 05:46 |
|
Articles in Press |
|
2026-03-17 05:46 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-04-28 01:37 |
|
Publish the Manuscript Online |
|
2026-05-11 09:00 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Minireviews |
| Article Title |
Unlocking pancreatic metabolic memory: Can early interventions reverse obesity and block diabetes before it strikes?
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yu-Jue Wang, Shuai-Yan Wang, Zi-Mu Li, Meng-Ying Zhao, Mo Zhou, Cong-Yi Xie, Jin-Ai Wang, Bin Xu, Guan-Hu Yang, Yun Liu and Tian-Cheng Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China Youth Science Fund Project |
No. 82305376 |
| Young Talent Support Program of the China Association for Acupuncture-Moxibustion |
No. 2024-2026ZGZJXH-QNRC005 |
| 2024 Jiangsu Provincial Young Scientific and Technological Talent Support Program |
No. JSTJ-2024-380 |
| Talent Cultivation Program for Young Researchers, Key Laboratory of the Ministry of Education Project |
No. Zyqt202501 and No. Zyqt202503 |
|
| Corresponding Author |
Tian-Cheng Xu, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn |
| Key Words |
Diabetes; Obesity; Metabolic Memory; Pancreas |
| Core Tip |
Sustained exposure of pancreatic macrophages to metabolic stress (e.g., obesity, type 2 diabetes) triggers epigenetic reprogramming, leading to the establishment of a persistent “metabolic memory”. This memory maintains chronic local inflammation in the pancreas even after external stimuli subside, resulting in continuous deterioration of β-cell function and thereby driving the progression of type 2 diabetes. Targeting this maladaptive memory through lifestyle interventions or epigenetic modulators represents a highly promising early intervention strategy to halt the disease progression. |
| Publish Date |
2026-05-11 09:00 |
| Citation |
Wang YJ, Wang SY, Li ZM, Zhao MY, Zhou M, Xie CY, Wang JA, Xu B, Yang GH, Liu Y, Xu TC. Unlocking pancreatic metabolic memory: Can early interventions reverse obesity and block diabetes before it strikes? World J Diabetes 2026; 17(5): 118754 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i5/118754.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i5.118754 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
