| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Case Report |
| Article Title |
Castleman disease variant of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome: A case report
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Lih Jen Paw, Juen Kiem Tan, Chia Xuan Teoh, Puteri Nur Athirah Megat Mohamad Aminuddin, Ahmad Farhan Agusalim, Xiong Khee Cheong, Alvin Oliver Payus, Wan Alina Khadijah Wan Nik Ahmad Mustafa, Ummul Afila Omar, Norlaila Mustafa, Guang Yong Chong, Nor Rafeah Tumian, S Fadilah Abdul Wahid, Chia Yin Chong, Hui Jan Tan and Rabani Remli |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Rabani Remli, Associate Professor, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia. rabaniremli@hctm.ukm.edu.my |
| Key Words |
Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome; Castleman disease; M-protein-negative; Demyelinating polyneuropathy; Vascular endothelial growth factor; Plasma cell disorder; Case report |
| Core Tip |
Castleman disease variant of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome is a rare and challenging multisystem disorder to manage, with atypical variants without detectable M-protein exceptionally uncommonly encountered. This case highlights the importance of recognising key clinical features and utilising supportive markers, such as vascular endothelial growth factor and histopathology. To improve functional outcomes, quality of life, and minimise long-term morbidity, early diagnosis enables timely systemic chemotherapy treatment and multidisciplinary supportive care. |
| Publish Date |
2026-03-16 09:13 |
| Citation |
Paw LJ, Tan JK, Teoh CX, Megat Mohamad Aminuddin PNA, Agusalim AF, Cheong XK, Payus AO, Wan Nik Ahmad Mustafa WAK, Omar UA, Mustafa N, Chong GY, Tumian NR, Abdul Wahid SF, Chong CY, Tan HJ, Remli R. Castleman disease variant of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome: A case report. World J Clin Cases 2026; 14(8): 118789 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i8/118789.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i8.118789 |
