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6/26/2026 10:03:12 AM | Browse: 4 | Download: 0
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Received |
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2026-01-14 00:29 |
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Peer-Review Started |
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2026-01-14 00:30 |
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First Decision by Editorial Office Director |
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2026-01-19 08:49 |
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Return for Revision |
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2026-01-19 08:49 |
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Revised |
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2026-01-26 09:08 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-06 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-06 08:32 |
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Articles in Press |
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2026-03-06 08:32 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-16 01:00 |
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Publish the Manuscript Online |
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2026-06-26 09:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Metabolic links between metabolic dysfunction-associated steatotic liver disease and primary biliary cholangitis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Stanislav Kotlyarov |
| Funding Agency and Grant Number |
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| Corresponding Author |
Stanislav Kotlyarov, PhD, Department of Nurse, Ryazan State Medical University, Vysokovoltnaya 9, Ryazan 390005, Russia. skmr1@yandex.ru |
| Key Words |
Primary biliary cholangitis; Metabolic dysfunction-associated steatotic liver disease; Adipokines; Adiponectin; Leptin; Immunometabolism; Gut microbiota; Oxidative stress; Mitochondrial dysfunction; Leptin/adiponectin ratio |
| Core Tip |
The increase in metabolic disorders has led to the comorbidity of primary biliary cholangitis (PBC) and metabolic dysfunction-associated steatotic liver disease (MASLD) becoming increasingly common. Beyond simple comorbidity, these conditions cause complex immunometabolic cross-talk involving common pathways of immune dysregulation, lipid metabolism alterations, adipokine imbalance, and gut microbiota dysfunction. Recent data suggest that in patients with PBC, concomitant MASLD disrupts the characteristic hyperadiponectinemia associated with cholestasis, leading to a specific adipokine profile with an elevated leptin/adiponectin ratio. This Editorial summarizes current understanding of the pathogenetic relationships between PBC and MASLD, analyzes new clinical data on their bidirectional effects, and identifies critical gaps in knowledge. Understanding these interactions is important for developing personalized therapeutic approaches and improving treatment outcomes for patients with this increasingly recognized dual pathology. |
| Publish Date |
2026-06-26 09:50 |
| Citation |
Kotlyarov S. Metabolic links between metabolic dysfunction-associated steatotic liver disease and primary biliary cholangitis. World J Hepatol 2026; 18(6): 118902
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i6/118902.htm |
| DOI |
https://doi.org/10.4254/wjh.118902 |
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