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5/27/2026 3:23:14 AM | Browse: 5 | Download: 1
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2026-01-26 00:46 |
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2026-01-26 00:47 |
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2026-03-02 08:49 |
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2026-03-02 08:49 |
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2026-03-10 14:09 |
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2026-04-08 02:43 |
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2026-04-08 10:29 |
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Articles in Press |
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2026-04-08 10:29 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-05-20 01:00 |
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Publish the Manuscript Online |
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2026-05-27 03:21 |
| ISSN |
1949-8470 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Minireviews |
| Article Title |
Molecular basis of radiation resistance in tardigrades and the medical implications
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hiroki Goto, Mariko Takano and Nuchjira Takheaw |
| Funding Agency and Grant Number |
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| Corresponding Author |
Hiroki Goto, Associate Professor, MD, PhD, Division of Radioisotope and Tumor Pathobiology, Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-Ku, Kumamoto 860-0811, Japan. hgoto20@kumamoto-u.ac.jp |
| Key Words |
Tardigrade; Damage suppressor; Cryptobiosis; Ionizing radiation; Reactive oxygen species |
| Core Tip |
Tardigrades exhibit extraordinary resistance to ionizing and ultraviolet radiation. Among the tardigrade-derived molecules linked to this resilience, damage suppressor binds to chromatin and mitigates both hydroxyl-radical-induced DNA breaks and ultraviolet-induced pyrimidine dimers. Recent studies have demonstrated that damage suppressor expression in mammalian cells reduces γ-H2AX foci by approximately 40% and prolongs cellular survival after irradiation. In this minireview, we highlight recent advances in understanding tardigrade radiation resistance and explore potential clinical applications for managing radiation-induced cellular injury. |
| Publish Date |
2026-05-27 03:21 |
| Citation |
Goto H, Takano M, Takheaw N. Molecular basis of radiation resistance in tardigrades and the medical implications. World J Radiol 2026; 18(5): 119372 |
| URL |
https://www.wjgnet.com/1949-8470/full/v18/i5/119372.htm |
| DOI |
https://dx.doi.org/10.4329/wjr.v18.i5.119372 |
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