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6/26/2026 10:03:12 AM | Browse: 4 | Download: 0
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Received |
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2026-02-02 05:34 |
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Peer-Review Started |
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2026-02-02 05:35 |
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First Decision by Editorial Office Director |
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2026-02-10 10:29 |
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Return for Revision |
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2026-02-10 10:29 |
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Revised |
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2026-02-24 06:50 |
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Publication Fee Transferred |
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2026-02-25 05:20 |
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Second Decision by Editor |
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2026-04-17 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-04-17 08:07 |
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Articles in Press |
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2026-04-17 08:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-16 01:04 |
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Publish the Manuscript Online |
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2026-06-26 09:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Basic Study |
| Article Title |
LECT2/Tie1/Src signaling regulates the oxidative stress response in endothelial cells and liver ischemia-reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Yang, Shi-Li Wu, Zhi-Hao Huang, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Yi Gao, Wei-Jie Zhou and Yuan Lin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program |
2022YFA1106700 |
| National Natural Science Foundation of China |
No. 82270645, No. 82570748 |
| National Natural Science Foundation of China |
No. 82200633, No. 92068206 |
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| Corresponding Author |
Yuan Lin, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Road, Guangzhou 510515, Guangdong Province, China. xiaoyuanlinz@163.com |
| Key Words |
Leukocyte-derived chemotaxin-2; Tie1; Src kinase; Endothelial cells; Oxidative stress; Ischemia-reperfusion injury; Liver injury |
| Core Tip |
This study elucidates a novel signaling mechanism in which leukocyte-derived chemotaxin-2 exacerbates hepatic ischemia-reperfusion injury by binding to Tie1 and activating Src kinase, thereby amplifying oxidative stress and endothelial cell damage. Targeting the leukocyte-derived chemotaxin-2/Tie1/Src axis represents a promising therapeutic strategy for mitigating liver ischemia-reperfusion injury, offering potential translational applications in liver surgery and transplantation. |
| Publish Date |
2026-06-26 09:50 |
| Citation |
Yang Y, Wu SL, Huang ZH, Dong MQ, Liu ZM, Xu M, Gao Y, Zhou WJ, Lin Y. LECT2/Tie1/Src signaling regulates the oxidative stress response in endothelial cells and liver ischemia-reperfusion injury. World J Hepatol 2026; 18(6): 119561
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i6/119561.htm |
| DOI |
https://doi.org/10.4254/wjh.119561 |
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