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8/13/2026 9:18:04 AM | Browse: 4 | Download: 0
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Received |
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2026-02-02 00:53 |
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Peer-Review Started |
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2026-02-02 00:54 |
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First Decision by Editorial Office Director |
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2026-02-06 10:21 |
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Return for Revision |
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2026-02-06 10:21 |
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Revised |
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2026-02-07 19:30 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-24 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-24 09:47 |
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Articles in Press |
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2026-03-24 09:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-06 07:24 |
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Publish the Manuscript Online |
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2026-08-13 07:25 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Prospective Study |
| Article Title |
Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Amira A A Othman, Magy Magdy Mohamed, Mona Mahmoud Eladl and Fatma M Attia Elsayed |
| Funding Agency and Grant Number |
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| Corresponding Author |
Amira A A Othman, Lecturer, MD, PhD, Principal Investigator, Department of Internal Medicine, Faculty of Medicine, Suez University, Cairo-Suez Road, Suez 43511, Egypt. amira.othman@med.suezuni.edu.eg |
| Key Words |
Neutrophil gelatinase-associated lipocalin; Renal Doppler; Acute kidney injury; Cirrhosis; Biomarkers; XGBoost; Resource-efficient |
| Core Tip |
Acute kidney injury (AKI) in cirrhosis is frequently underdiagnosed in resource-limited settings due to the unreliability of serum creatinine. This prospective Egyptian study, conducted in the hepatitis C virus-endemic population, demonstrates that integrating serum neutrophil gelatinase-associated lipocalin, cystatin C, and renal resistive index enables earlier AKI detection, accurate subtyping (pre-renal, hepatorenal syndrome, acute tubular necrosis), and improved short-term prognostication. We provide the first region-specific evidence that a simple neutrophil gelatinase-associated lipocalin-renal resistive index-based algorithm, supported by point-of-care ultrasound, can guide clinical triage and reduce unnecessary intensive care unit utilization in real-world Egyptian practice. These findings offer a practical, scalable diagnostic framework for cirrhosis-associated AKI in low-income and middle-income countries. |
| Publish Date |
2026-08-13 07:25 |
| Citation |
Othman AAA, Mohamed MM, Eladl MM, Elsayed FMA. Integrated biomarkers and renal Doppler for early acute kidney injury diagnosis in hepatitis C virus cirrhosis. World J Nephrol 2026; 15(3): 119581
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| URL |
https://www.wjgnet.com/2220-6124/full/v15/i3/119581.htm |
| DOI |
https://doi.org/10.5527/wjn.119581 |
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