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4/15/2026 8:59:02 AM | Browse: 19 | Download: 35
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Received |
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2026-02-26 02:50 |
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Peer-Review Started |
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2026-02-26 02:52 |
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First Decision by Editorial Office Director |
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2026-03-04 09:02 |
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Return for Revision |
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2026-03-04 09:02 |
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Revised |
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2026-03-08 17:16 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-03-19 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-03-19 07:46 |
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Articles in Press |
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2026-03-19 07:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-04-07 00:48 |
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Publish the Manuscript Online |
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2026-04-15 07:40 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Case Report |
| Article Title |
Size-biology paradox in ampullary tumours - large-cell neuroendocrine carcinoma of the ampulla of Vater: A case report
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Evangelia Florou, Abijith Velayutham, Yoh Zen, Justin Waters and Parthi Srinivasan |
| Funding Agency and Grant Number |
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| Corresponding Author |
Evangelia Florou, MD, Department of Hepato-Pancreato-Biliary Surgery, King’s College Hospital, Denmark Hill, London SE5 9RS, United Kingdom. e.florou@nhs.net |
| Key Words |
Ampullary carcinoma; Neuroendocrine carcinoma; Large-cell neuroendocrine carcinoma; Pancreaticoduodenectomy; Adjuvant chemotherapy; Ampulla of Vater; Case report |
| Core Tip |
Large-cell neuroendocrine carcinoma (LCNEC) of the ampulla of Vater is a rare and aggressive malignancy that may present as a small lesion but requires oncologically intensive management. This striking discordance between tumour size, anatomical location, and biological behaviour underpins the size-biology paradox observed in ampullary LCNEC and highlights the importance of accurate histopathological classification and multidisciplinary oncological management. |
| Publish Date |
2026-04-15 07:40 |
| Citation |
Florou E, Velayutham A, Zen Y, Waters J, Srinivasan P. Size-biology paradox in ampullary tumours - large-cell neuroendocrine carcinoma of the ampulla of Vater: A case report. World J Clin Cases 2026; 14(12): 120145 |
| URL |
https://www.wjgnet.com/2307-8960/full/v14/i12/120145.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v14.i12.120145 |
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