BPG is committed to discovery and dissemination of knowledge
Featured Articles
6/26/2026 10:03:12 AM | Browse: 4 | Download: 0
 |
Received |
|
2026-02-27 03:14 |
|
Peer-Review Started |
|
2026-02-27 03:14 |
|
First Decision by Editorial Office Director |
|
2026-03-20 11:18 |
|
Return for Revision |
|
2026-03-21 03:10 |
|
Revised |
|
2026-04-04 15:15 |
|
Publication Fee Transferred |
|
2026-04-05 07:49 |
|
Second Decision by Editor |
|
2026-05-11 02:44 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2026-05-11 09:15 |
|
Articles in Press |
|
2026-05-11 09:15 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2026-06-04 04:01 |
|
Publish the Manuscript Online |
|
2026-06-26 09:50 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Dong Yin, Wei-Yu Jiang, Yu-Ting Huang, Shu-Ping Zhou and Yin-Ci Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Health Research Program of Anhui |
No. AHWJ2023A30019 |
| Clinical and Translational Research Project of Anhui Province |
No. 202527c10020090 and No. 202304295107020036 |
| University-Industry Collaborative Education Program |
No. 230907010211931 |
|
| Corresponding Author |
Yin-Ci Zhang, The First Hospital, Anhui University of Science and Technology, No.203 Huaibin Road, Tianjia'an District, Huainan 232000, Anhui Province, China. 13345543605@163.com |
| Key Words |
Methionine; Hepatocellular carcinoma; Epithelial-mesenchymal transition; Ferroptosis; ARNT2; UBE2Z |
| Core Tip |
Aberrant methionine (Met) metabolism critically promotes the progression of hepatocellular carcinoma (HCC). Met deficiency may induce ferroptosis and inhibit epithelial-mesenchymal transition through the ARNT2/UBE2Z axis, thereby suppressing HCC progression, whereas Met supplementation reverses these effects. Furthermore, high expression levels of ARNT2 and UBE2Z predict unfavorable prognosis in HCC patients. Collectively, these findings indicate that the Met-ARNT2/UBE2Z pathway may serve as a novel anti-HCC therapeutic target. |
| Publish Date |
2026-06-26 09:50 |
| Citation |
Yin DD, Jiang WY, Huang YT, Zhou SP, Zhang YC. Methionine depletion inhibits hepatocellular carcinoma by inducing ferroptosis and suppressing epithelial-mesenchymal transition through the ARNT2/UBE2Z pathway. World J Hepatol 2026; 18(6): 120427
|
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i6/120427.htm |
| DOI |
https://doi.org/10.4254/wjh.120427 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
