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9/7/2026 6:12:35 AM | Browse: 6 | Download: 0
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Received |
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2026-03-03 03:18 |
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Peer-Review Started |
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2026-03-03 03:19 |
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First Decision by Editorial Office Director |
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2026-03-20 11:31 |
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Return for Revision |
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2026-03-20 11:31 |
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Revised |
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2026-04-18 15:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-09 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-09 08:30 |
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Articles in Press |
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2026-06-09 08:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-03 07:33 |
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Publish the Manuscript Online |
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2026-09-07 02:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Adenomatous polyposis coli promoter abnormalities in familial adenomatous polyposis and gastric adenocarcinoma and proximal polyposis of the stomach
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kenichi Taguchi, Masaya Iwamuro, Xueni Liu, Chikako Shibata, Seiji Kawano and Motoyuki Otsuka |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science KAKENHI |
No. JP25K10425 and No. JP25K22578 |
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| Corresponding Author |
Masaya Iwamuro, Assistant Professor, MD, PhD, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-Cho, Kita-Ku, Okayama 700-8558, Japan. pr145h2k@okayama-u.ac.jp |
| Key Words |
Adenomatous polyposis coli; Promoter 1B; Familial adenomatous polyposis; Gastric adenocarcinoma and proximal polyposis of the stomach; Yin Yang 1; Deletion; Single-nucleotide variant |
| Core Tip |
Abnormalities in the adenomatous polyposis coli promoter region are among the causes of familial adenomatous polyposis in patients without pathogenic variants in the coding region, as well as gastric adenocarcinoma and proximal polyposis of the stomach. In the present systematic review, the adenomatous polyposis coli promoter-region abnormalities were classified as follows: Deletions limited to promoter 1B; variants affecting the Yin Yang 1 (YY1) binding site; point variants outside the YY1 binding site; and large deletions or structural alterations encompassing the entire promoter-region. The variants affecting the YY1 binding site were further subclassified according to clinical phenotype. |
| Publish Date |
2026-09-07 02:26 |
| Citation |
Taguchi K, Iwamuro M, Liu X, Shibata C, Kawano S, Otsuka M. Adenomatous polyposis coli promoter abnormalities in familial adenomatous polyposis and gastric adenocarcinoma and proximal polyposis of the stomach. World J Gastroenterol 2026; 32(38): 120596
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i38/120596.htm |
| DOI |
https://doi.org/10.3748/wjg.120596 |
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