Publication Name	World Journal of Gastroenterology
Manuscript ID	12072
Country	United States

Received	2014-06-20 08:18
Peer-Review Started	2014-06-20 21:02
First Decision by Editorial Office Director
Return for Revision	2014-08-08 13:50
Revised	2014-08-16 05:16
Publication Fee Transferred
Second Decision by Editor	2014-09-29 17:08
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-09-29 17:10
Articles in Press	2014-09-30 10:52
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-09 15:28
Publish the Manuscript Online	2015-01-20 20:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Physiology
Manuscript Type	Autobiography
Article Title	Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Sabrina L McIlwrath and Karin N Westlund
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health NINDS R01 NS39041
Corresponding Author	Karin N Westlund, PhD, Professor, Department of Physiology, University of Kentucky, MS-508 Medical Center, 800 Rose St., Lexington, KY 40536-0298, United States. kwhigh2@uky.edu
Key Words	Lieber-DeCarli diet; Orphanin FQ receptor; Metabotropic glutamate receptor; Liver steatosis; Pain; Behavior; Glucose tolerance; Type 3c diabetes mellitus
Core Tip	Chronic pancreatitis is a progressive and potentially fatal disease caused by persistent unresolved inflammation and pancreatic fibrosis. It can be accompanied by intractable abdominal pain and progress to type 3c diabetes mellitus (T3cDM) and pancreatic cancer. Animal models of acute pancreatitis are typically chemically induced, invasive, of short duration, and have a high mortality rate. This study characterizes a diet-induced chronic rat model closely mimicking poor human dietary choices to investigate therapies for alcoholic chronic pancreatitis with developing T3cDM. The efficacy of acute opioid and non-opioid pharmacological interventions are compared to morphine in pain-related behavior tests.
Publish Date	2015-01-20 20:12
Citation	McIlwrath SL, Westlund KN. Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats. World J Gastroenterol 2015; 21(3): 836-853
URL	http://www.wjgnet.com/1007-9327/full/v21/i3/836.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i3.836

Full Article (PDF)	WJG-21-836.pdf
Full Article (Word)	WJG-21-836.doc