Publication Name	World Journal of Hematology
Manuscript ID	12129
Country	Netherlands

Received	2014-06-23 16:23
Peer-Review Started	2014-06-23 19:59
To Make the First Decision	2014-08-14 14:39
Return for Revision	2014-08-18 09:39
Revised	2014-11-15 00:00
Second Decision	2015-04-20 11:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-04-30 11:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-06 18:07
Publish the Manuscript Online	2015-08-20 08:49

ISSN	2218-6204 (online)
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Category	Hematology
Manuscript Type	Review
Article Title	European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms
Manuscript Source	Unsolicited Manuscript
All Author List	Jan Jacques Michiels, Fransje Valster, Jenne Wielenga, Katrien Schelfout and Hendrik De Raeve
Funding Agency and Grant Number
Corresponding Author	Jan Jacques Michiels, MD, PhD, Investigator, Senior Internist, International Hematology and Bloodcoagulation Research Center, Goodheart Institute and Foundation in Nature Medicine, European Working Group on Myeloproliferative Neoplasms, Erasmus Tower, Veenmos 13, 3069 AT Rotterdam, The Netherlands. goodheartcenter@upcmail.nl
Key Words	Myeloproliferative disorders; Essential thrombocythemia; Primary megakaryocytic granulocytic myeloproliferation; Myelofibrosis; JAK2V617F mutation; MPL515 mutation; Calreticulin mutation; JAK2 wild type; Myeloproliferative neoplasm; Bone marrow pathology; Polycythemia vera
Core Tip	The 2015 World Health Organization-Clinical Molecular and Pathological criteria define three pheno-types of JAK2V617F mutated myeloproliferative neoplasms (MPNs) essential thrombocythemia (ET), prodromal polycythemia vera (PV), prodromal PV, hyper-cellular megakaryocytic-granulocytic myelo-proliferation and classical PV vs the JAK2 exon 12 mutated idiopathic eryhrocythemia and PV. MPL515 mutated JAK2 wild type ET and myelofibrosis is a distinct thrombocythemia without features of PV in blood and bone marrow. Calreticulin mutated JAK2/MPL wild type ET and myelofibrosis is the third thrombocythemia entity with characteristic features of primary megakaryocytic granulocytic myeloproliferation in the bone marrow, which are not seen in JAK2 and MPL mutated MPNs. MPN disease burden is best reflected by the degree of anemia and splenomegaly on top of mutation allele burden, bone marrow cellularity and increase of reticulin fibrosis.
Publish Date	2015-08-20 08:49
Citation	Michiels JJ, Valster F, Wielenga J, Schelfout K, De Raeve H. European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms. World J Hematol 2015; 4(3): 16-53
URL	http://www.wjgnet.com/2218-6204/full/v4/i3/16.htm
DOI	http://dx.doi.org/10.5315/wjh.v4.i3.16

Full Article (PDF)	WJH-4-16.pdf
Full Article (Word)	WJH-4-16.doc
Manuscript File	12129-Review.docx
Answering Reviewers	12129-Answering reviewers.pdf
Audio Core Tip	12129-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	12129-Conflict-of-interest statement.pdf
Copyright License Agreement	12129-Copyright assignment.pdf
Peer-review Report	12129-Peer-review(s).pdf
Scientific Misconduct Check	12129-Scientific misconduct check.pdf
Scientific Editor Work List	12129-Scientific editor work list.pdf