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7/24/2026 8:38:11 AM | Browse: 112 | Download: 403
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Received |
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2026-03-24 09:26 |
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Peer-Review Started |
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2026-03-24 09:26 |
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2026-04-03 10:06 |
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2026-04-06 06:29 |
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2026-04-14 06:08 |
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2026-04-15 08:22 |
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2026-06-01 02:41 |
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Final Decision by Editorial Office Director |
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2026-06-01 09:30 |
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2026-06-01 09:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-06-25 02:16 |
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Publish the Manuscript Online |
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2026-07-24 07:03 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Activated cGAS-STING signaling promotes malignancy in metabolic dysfunction-associated fatty liver disease via mitochondrial DNA and immune cell dysfunction
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng-Ya Zhou, Rong-Fei Fang, Hao Tang, Xiao-Xiao Xia, Qun Xie, Deng-Fu Yao, Wen-Li Sai and Min Yao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation |
No. 32470985 |
| Nantong Science and Technology Programs |
No. MS2024051 |
| Nantong Control of Infectious Diseases |
No. NTCRB2025016 |
| Nantong Health Commission of China |
No. QN2025064 |
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| Corresponding Author |
Min Yao, PhD, Postdoc, Professor, Vice Director, Department of Immunology, Medical School of Nantong University, Nantong University, No. 19 Qixiu Road, Nantong 226001, Jiangsu Province, China. erbei@ntu.edu.cn |
| Key Words |
Metabolic dysfunction-associated fatty liver disease; Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes; Hepatocellular carcinoma; Mitochondrial damage; Single-cell sequencing |
| Core Tip |
Hepatocyte cyclic guanosine monophosphate-adenosine monophosphate synthase, as a DNA sensor, recognizes damaged mitochondrial DNA with aberrant lipid metabolism to activate stimulator of interferon genes to trigger the expressions of inflammatory factors, such as type-I interferon, which might be closely related to metabolic dysfunction-associated fatty liver disease (MAFLD) progression. However, the molecular mechanisms underlying MAFLD malignancy are still unclear. In this study, the activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes signaling pathway was systematically evaluated in a lipid accumulation model, and the pathogenesis of MAFLD was clarified by evaluating the interactions among hepatocyte injury, inflammatory factors, and immune cells in hepatocarcinogenesis. |
| Publish Date |
2026-07-24 07:03 |
| Citation |
Zhou MY, Fang RF, Tang H, Xia XX, Xie Q, Yao DF, Sai WL, Yao M. Activated cGAS-STING signaling promotes malignancy in metabolic dysfunction-associated fatty liver disease via mitochondrial DNA and immune cell dysfunction. World J Hepatol 2026; 18(7): 121423
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i7/121423.htm |
| DOI |
https://doi.org/10.4254/wjh.121423 |
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