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7/20/2026 7:08:49 AM | Browse: 27 | Download: 20
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2026-03-30 01:58 |
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2026-03-31 03:33 |
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2026-06-16 02:34 |
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2026-07-20 07:08 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Dose-dependent efficacy of olezarsen in high-risk hypertriglyceridemia: A meta-analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Vyom Patel, Rohab Sohail, Madihah Alam, Shahryar Chaudhry, Samar Mehdi, Simran Patel, Rohan Patel, Ridda Khattak, Zaraq Khan and Manan Patel |
| Funding Agency and Grant Number |
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| Corresponding Author |
Vyom Patel, MD, Principal Investigator, Department of Internal Medicine, Indiana University School of Medicine, INDIANA UNIVERSITY SCHOOL OF MEDICINE, Department of Internal Medicine, Indiana University School of Medicine, Southwest Internal Medicine Residency Program, Evansville, Indiana, USA. Electronic address: vyompate@iu.edu, Evansville, IN 47591, United States. vyompate@iu.edu |
| Key Words |
Olezarsen; Dose-dependent effectiveness; Side-effects; Apolipoprotein C-III; Hypertriglyceridemia |
| Core Tip |
This meta-analysis of three randomized controlled trials is the first to directly compare olezarsen 80 mg vs 50 mg in patients with high-risk hypertriglyceridemia. While the 80 mg dose produced a statistically significant incremental reduction in apolipoprotein C-III (apoC-III), no significant differences were observed in triglyceride, non-high-density lipoprotein cholesterol, or safety outcomes. These findings suggest that higher dosing confers limited added benefit beyond apoC-III suppression, though equivalence cannot be established from the available evidence. |
| Publish Date |
2026-07-20 07:08 |
| Citation |
Patel V, Sohail R, Alam M, Chaudhry S, Mehdi S, Patel S, Patel R, Khattak R, Khan Z, Patel M. Dose-dependent efficacy of olezarsen in high-risk hypertriglyceridemia: A meta-analysis. World J Cardiol 2026; 18(7): 121611
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| URL |
https://www.wjgnet.com/1949-8462/full/v18/i7/121611.htm |
| DOI |
https://doi.org/10.4330/wjc.121611 |
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