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7/21/2026 8:56:19 AM | Browse: 4 | Download: 0
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Received |
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2026-04-17 01:09 |
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Peer-Review Started |
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2026-04-17 01:11 |
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First Decision by Editorial Office Director |
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2026-04-30 08:53 |
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Return for Revision |
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2026-04-30 08:53 |
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Revised |
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2026-05-06 07:08 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-06-09 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-06-09 06:45 |
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Articles in Press |
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2026-06-09 06:45 |
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Edit the Manuscript by Language Editor |
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2026-06-22 03:43 |
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Typeset the Manuscript |
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2026-06-29 12:20 |
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Publish the Manuscript Online |
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2026-07-21 07:21 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Review |
| Article Title |
Dickkopf-1 in rheumatoid arthritis: Mechanistic insights, imaging associations, and emerging therapeutic strategies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Adithya Vikram Rajesh, Arunagiri Gunasekar, Naveen Jeyaraman, Sanjeevi Bharadwaj, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman |
| Funding Agency and Grant Number |
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| Corresponding Author |
Madhan Jeyaraman, Associate Professor, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@drmgrdu.ac.in |
| Key Words |
Dickkopf-1; Rheumatoid arthritis; Wnt/β-catenin; Osteoprotegerin; RANKL; Osteoclastogenesis |
| Core Tip |
Dickkopf-1 (DKK-1) is a key regulator of bone remodeling in rheumatoid arthritis, driving erosion by inhibiting Wnt signaling, suppressing osteoblasts, and enhancing RANKL-mediated osteoclastogenesis. Elevated DKK-1 correlates with inflammation, autoantibodies, disease activity, and imaging indices, while genetic variants modulate risk. Though blockade shows therapeutic promise, safety concerns and assay variability remain. DKK-1 offers a multidimensional biomarker for prognosis, monitoring, and precision-targeted therapy in rheumatoid arthritis. |
| Publish Date |
2026-07-21 07:21 |
| Citation |
Rajesh AV, Gunasekar A, Jeyaraman N, Bharadwaj S, Nallakumarasamy A, Muthu S, Jeyaraman M. Dickkopf-1 in rheumatoid arthritis: Mechanistic insights, imaging associations, and emerging therapeutic strategies. World J Clin Cases 2026; 14(21): 121907
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| URL |
https://www.wjgnet.com/2307-8960/full/v14/i21/121907.htm |
| DOI |
https://doi.org/10.12998/wjcc.121907 |
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