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2/11/2015 8:57:00 AM | Browse: 546 | Download: 1560
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Received |
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2014-06-29 13:56 |
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Peer-Review Started |
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2014-06-29 19:02 |
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To Make the First Decision |
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2014-09-16 10:51 |
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Return for Revision |
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2014-09-18 09:20 |
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Revised |
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2014-10-29 12:34 |
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Second Decision |
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2014-11-28 14:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-12-10 17:25 |
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Articles in Press |
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2014-12-10 17:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-30 13:27 |
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Publish the Manuscript Online |
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2015-02-05 14:08 |
| ISSN |
1949-8454 (online) |
| Open Access |
This article is an open-access article which was
selected by an in-house editor and fully peer-reviewed by external
reviewers. It is distributed in accordance with the Creative
Commons Attribution Non Commercial (CC BY-NC 4.0) license,
which permits others to distribute, remix, adapt, build upon this
work non-commercially, and license their derivative works on
different terms, provided the original work is properly cited and
the use is non-commercial. See: http://creativecommons.org/
licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing
Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Chronic alcohol consumption potentiates the developmentof diabetes through pancreatic b-cell dysfunction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ji Yeon Kim, Dae Yeon Lee, Yoo Jeong Lee, Keon Jae Park, Kyu Hee Kim, Jae Woo Kim and Won-Ho Kim |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Korean National Institute of Health |
4845-302-201-13 |
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| Corresponding Author |
Won-Ho Kim, PhD, Division of
Metabolic Diseases, Center for Biomedical Science, National
Institute of Health, #187 Osong Saengmyeong2-ro, Osong-eup,
Heungdeok-gu, Cheongju, Chungbuk 363-700,
South Korea. jhkwh@nih.go.kr |
| Key Words |
Ethanol consumption; Type 2 diabetes; Pancreatic β-cells; Glucokinase; Metabolic syndrome |
| Core Tip |
Chronic ethanol consumption induces Glucokinase
(GCK) downregulation and inactivation through
Tyr nitration, resulting in pancreatic β-cell apoptosis
and dysfunction. Additionally, GCK proteins nitrated
following ethanol treatment may be more susceptible
to ubiquitination and consequent degradation than
are native proteins of control cells. Peroxynitritemediated
GCK downregulation or inactivation may
perturb glucose metabolism and cellular antioxidant
defense mechanisms, increasing susceptibility to
insulin resistance and type-2 diabetes. Furthermore,
peroxynitrite-generated activating transcription factor
3 may play as a major upstream regulator of GCK downregulation in β-cell dysfunction and apoptosis. |
| Publish Date |
2015-02-05 14:08 |
| Citation |
Kim JY, Lee DY, Lee YJ, Park KJ, Kim KH, Kim JW, Kim
WH. Chronic alcohol consumption potentiates the development
of diabetes through pancreatic β-cell dysfunction. World J Biol
Chem 2015; 6(1): 1-15 |
| URL |
http://www.wjgnet.com/1949-8454/full/v6/i1/1.htm |
| DOI |
http://dx.doi.org/10.4331/wjbc.v6.i1.1 |
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