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8/20/2026 7:50:02 AM | Browse: 2 | Download: 9
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Received |
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2026-04-30 03:37 |
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2026-04-30 03:38 |
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2026-06-22 01:19 |
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2026-07-05 12:17 |
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2026-07-20 02:35 |
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2026-07-20 07:05 |
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2026-07-20 07:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-06 07:53 |
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Publish the Manuscript Online |
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2026-08-20 06:49 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Emergency Medicine |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Effectiveness and safety of antifibrinolytic agents in the management of pulmonary haemorrhage: A systematic review with narrative synthesis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yasmin Kabir and Jonathan Soldera |
| Funding Agency and Grant Number |
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| Corresponding Author |
Jonathan Soldera, Gastroenterology and Acute Medicine, University of South Wales in association with Learna Ltd., University of South Wales, Llantwit Road, Pontypridd, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com |
| Key Words |
Pulmonary hemorrhage; Hemoptysis; Tranexamic acid; Antifibrinolytic agents; Administration; Inhalation |
| Core Tip |
This systematic review with narrative synthesis shows that the apparent effect of tranexamic acid (TXA) on haemoptysis outcomes depends heavily on clinical context: Nebulised TXA improves bleeding control in stable, non-massive haemoptysis, whereas higher mortality reported with TXA in intensive care cohorts most likely reflects confounding by indication rather than drug harm. Route, severity, and population must therefore be considered together when interpreting TXA evidence, rather than treating haemoptysis as a single condition or TXA exposure as uniform across settings. |
| Publish Date |
2026-08-20 06:49 |
| Citation |
Kabir Y, Soldera J. Effectiveness and safety of antifibrinolytic agents in the management of pulmonary haemorrhage: A systematic review with narrative synthesis. World J Clin Cases 2026; 14(24): 122847
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| URL |
https://www.wjgnet.com/2307-8960/full/v14/i24/122847.htm |
| DOI |
https://doi.org/10.12998/wjcc.122847 |
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