Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	12293
Country	Australia

Received	2014-06-30 20:08
Peer-Review Started	2014-07-01 09:43
To Make the First Decision	2014-08-14 14:35
Return for Revision	2014-08-18 10:44
Revised	2014-08-29 11:55
Second Decision	2014-09-24 16:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-24 16:23
Articles in Press	2014-09-24 16:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-06 08:26
Publish the Manuscript Online	2014-12-08 16:35

ISSN	2220-3176 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Review
Article Title	Reverse genetics: Unlocking the secrets of negative sense RNA viral pathogens
Manuscript Source	Invited Manuscript
All Author List	Kathryn Edenborough and Glenn A Marsh
Funding Agency and Grant Number
Corresponding Author	Glenn A Marsh, PhD, Australian Animal Health Laboratory, CSIRO, 5 Portarlington Rd, East Geelong, 3219 Victoria, Australia. glenn.marsh@csiro.au
Key Words	Reverse genetics; Viral pathogen; Negative sense RNA viruses; Influenza A virus; Ebola virus; Rabies virus; Hendra virus; Nipah virus
Core Tip	Several negative sense RNA viruses are capricious, pandemic threats and give no quarter to their human hosts. Reverse genetic approaches have been valuable for discovery of key virulence factors mediating disease with the aim of treatment and vaccine development, and knowledge acquisition to genetically map pathogenic potential. Despite the value of the reverse genetics approach current systems are limited by molecular cloning procedures that do not enable reproduction of genetically heterogeneous virus populations that circulate in nature. Advances in molecular biology may facilitate production of genetically diverse viral populations that better represent natural isolates.
Publish Date	2014-12-08 16:35
Citation	Edenborough K, Marsh GA. Reverse genetics: Unlocking the secrets of negative sense RNA viral pathogens. World J Clin Infect Dis 2014; 4(4): 16-26
URL	http://www.wjgnet.com/2220-3176/full/v4/i4/16.htm
DOI	http://dx.doi.org/10.5495/wjcid.v4.i4.16

Full Article (PDF)	WJCID-4-16.pdf
Full Article (Word)	WJCID-4-16.doc
Manuscript File	12293-Review.docx
Answering Reviewers	12293-Answering reviewers.pdf
Copyright License Agreement	12293-Copyright assignment.pdf
Peer-review Report	12293-Peer review(s).pdf
Scientific Misconduct Check	12293-CrossCheck.jpg
Scientific Editor Work List	12293-Scientific editor work list.pdf