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8/18/2026 8:09:17 AM | Browse: 5 | Download: 0
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Received |
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2026-05-18 07:42 |
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Peer-Review Started |
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2026-05-18 07:42 |
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First Decision by Editorial Office Director |
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2026-06-05 06:04 |
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Return for Revision |
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2026-06-05 07:06 |
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Revised |
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2026-06-08 08:45 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-07-17 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-07-17 06:57 |
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Articles in Press |
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2026-07-17 06:57 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-08-11 00:45 |
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Publish the Manuscript Online |
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2026-08-18 03:51 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Peribiliary and colonic crypt glands in primary sclerosing cholangitis and inflammatory bowel disease pathogenesis: New research perspectives
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vasiliy Ivanovich Reshetnyak, Alexandra Andreevna Reshetnyak and Igor Veniaminovich Maev |
| Funding Agency and Grant Number |
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| Corresponding Author |
Vasiliy Ivanovich Reshetnyak, Full Professor, MD, PhD, Department of Propaedeutics of Internal Diseases and Gastroenterology, Russian University of Medicine, No. 20 Delegatskaya Street, Moscow 127473, Russia. vasiliy.reshetnyak@yandex.ru |
| Key Words |
Primary sclerosing cholangitis; Inflammatory bowel disease; Peribiliary glands; Glands of colon crypts; Mucins of the bile ducts; Mucins of the colon mucosa; Fucosyltransferase 2 |
| Core Tip |
This review presents a novel hypothesis explaining the pathogenesis of primary sclerosing cholangitis (PSC), focusing on the key role of peribiliary glands (PBGs) and colonic crypt glands as a common morphofunctional structure linking pathology of bile ducts and colon. The hypothesis proposes that simultaneous structural and functional impairment of these mucin-producing glands may trigger PSC development. The unifying mechanism, which links PSC and inflammatory bowel disease (IBD) through dysfunction PBGs and colonic crypt glands, probably closely related to mutations in the FUT2 gene affecting fucosylation of protective mucins in bile ducts and colonic mucosa. This hypothesis explains key clinical features of PSC: (1) Selective involvement of extrahepatic and large intrahepatic bile ducts; (2) Formation of characteristic concentric strictures; (3) Strong association between PSC in IBD; (4) Sparing of small intralobular and interlobular bile ducts; and (5) Increased risk of cholangiocellular carcinoma and colorectal cancer. The proposed mechanism provides a comprehensive framework for understanding PSC pathogenesis and identifies potential therapeutic targets. |
| Publish Date |
2026-08-18 03:51 |
| Citation |
Reshetnyak VI, Reshetnyak AA, Maev IV. Peribiliary and colonic crypt glands in primary sclerosing cholangitis and inflammatory bowel disease pathogenesis: New research perspectives. World J Hepatol 2026; 18(8): 123377
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i8/123377.htm |
| DOI |
https://doi.org/10.4254/wjh.123377 |
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