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10/21/2026 7:25:05 AM | Browse: 3 | Download: 0
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Received |
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2026-06-24 07:38 |
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Peer-Review Started |
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2026-06-24 07:38 |
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First Decision by Editorial Office Director |
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2026-07-23 07:18 |
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2026-08-05 04:40 |
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Second Decision by Editor |
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2026-09-17 02:42 |
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Final Decision by Editorial Office Director |
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2026-09-17 09:37 |
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Articles in Press |
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2026-09-17 09:37 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-09-30 14:49 |
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Publish the Manuscript Online |
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2026-10-21 02:09 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Autoimmune hepatitis in the context of systemic lupus erythematosus: A narrative review of overlap syndrome and lupus-associated hepatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Abdelwahap Elghezewi and Mujtaba Mohamed |
| Funding Agency and Grant Number |
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| Corresponding Author |
Abdelwahap Elghezewi, Academic Fellow, FACG, FACP, Section of Gastroenterology, Marshall University, 249 15th Street, Huntington, WV 25701, United States. elghezewia@marshall.edu |
| Key Words |
Autoimmune hepatitis; Systemic lupus erythematosus; Overlap syndrome; Lupus hepatitis; autoantibodies; Liver biopsy; Immunopathogenesis |
| Core Tip |
Liver enzyme abnormalities affect up to 60% of patients with systemic lupus erythematosus, yet true autoimmune hepatitis (AIH)-systemic lupus erythematosus overlap is rare and often over-diagnosed because antinuclear antibodies and hypergammaglobulinemia inflate International AIH Group scores. AIH is cell-mediated and can progress to cirrhosis, whereas lupus hepatitis is immune complex-mediated with complement consumption and an excellent prognosis. Liver biopsy with C1q immunofluorescence, anti-smooth muscle and anti-soluble liver antigen/liver-pancreas antibodies, and complement levels are key discriminators. Mycophenolate mofetil is the preferred dual-purpose agent; validated overlap-specific criteria remain needed. |
| Publish Date |
2026-10-21 02:09 |
| Citation |
Elghezewi A, Mohamed M. Autoimmune hepatitis in the context of systemic lupus erythematosus: A narrative review of overlap syndrome and lupus-associated hepatitis. World J Hepatol 2026; 18(10): 124793
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| URL |
https://www.wjgnet.com/1948-5182/full/v18/i10/124793.htm |
| DOI |
https://doi.org/10.4254/wjh.124793 |
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