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6/1/2015 10:01:00 AM | Browse: 745 | Download: 1325
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Received |
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2014-07-25 18:05 |
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Peer-Review Started |
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2014-07-26 13:39 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-10-11 14:56 |
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Revised |
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2014-11-10 03:11 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-12-16 15:29 |
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Second Decision by Editor-in-Chief |
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2014-12-17 03:19 |
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Final Decision by Editorial Office Director |
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2014-12-22 17:04 |
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Articles in Press |
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2014-12-22 17:25 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-05-15 19:36 |
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Publish the Manuscript Online |
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2015-05-30 13:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Linda S Gutierrez, Jun Ling, Derek Nye, Konstantina Papathomas and Catherine Dickinson |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health |
R15 DK067901-02 |
| Howard Hughes Medical Institute |
52006328 |
| Wilkes Mentoring funds and institutional funds from Wilkes University and TCMC |
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| Corresponding Author |
Linda S Gutierrez, MD, Department of Biology and Health Sciences, Wilkes University, 230 Cohen Science Center, 84 West South Street, Wilkes-Barre, PA 18766, United States. linda.gutierrez@wilkes.edu |
| Key Words |
Thrombospondin 1; ABT-898; ABT-510; Angiogenesis; Inflammatory bowel disease; Dextran sodium sulfate model; Interleukin-6; STAT-3 |
| Core Tip |
Inflammatory bowel disease is still incurable and a major burden in the patient’s life and health care system. The discovery of new and safe therapeutic alternatives is urgently needed. This study tested the efficacy of a new thrombospondin- derived peptide, ABT-898 in a murine model of colitis. Our results indicate that this peptide was able to ameliorate inflammation and angiogenesis. In addition, mice treated with ABT-898 showed significant decrease of plasmatic Interleukin-6 and lesser activation of signal transducer and activator of transcription 3 in colitic lesions. These findings suggest that ABT-898 may indeed be an alternative treatment for inflammatory bowel disease. |
| Publish Date |
2015-05-30 13:32 |
| Citation |
Gutierrez LS, Ling J, Nye D, Papathomas K, Dickinson C. Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model. World J Gastroenterol 2015; 21(20): 6157-6166
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| URL |
http://www.wjgnet.com/1007-9327/full/v21/i20/6157.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i20.6157 |
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