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11/10/2026 3:37:09 AM | Browse: 5 | Download: 1
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2026-09-11 06:51 |
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Peer-Review Started |
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2026-09-21 08:11 |
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2026-10-08 05:53 |
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2026-10-16 13:16 |
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2026-11-02 02:18 |
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2026-11-02 02:56 |
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Articles in Press |
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2026-11-02 02:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-11-05 03:31 |
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Publish the Manuscript Online |
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2026-11-10 01:43 |
| ISSN |
2218-5836 (online) |
| Open Access |
Open-Access: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Minireviews |
| Article Title |
Natural bioactive compounds in estrogen deficiency-induced osteoporosis: Classification and an integrated gut microbiota-metabolite-immune-bone framework
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Long Luo, Tao Zhang and Wen-Sheng Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Graduate Research and Innovation Project of Baotou Medical College |
BYKYCX202606 |
| Natural Science Foundation of Inner Mongolia |
2022MS08039 |
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| Corresponding Author |
Wen-Sheng Xu, PhD, Department of Joint Surgery, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, No. 41 Linyin Road, Kundulun District, Baotou 014000, Inner Mongolia Autonomous Region, China. xwsoye@126.com |
| Key Words |
Natural bioactive compounds; Postmenopausal osteoporosis; Gut microbiota; Phytoestrogens; Short-chain fatty acids; Th17/Treg; Microrna; Extracellular vesicles; Gut-bone axis |
| Core Tip |
This minireview introduces a microbiota-dependent classification of natural bioactive compounds for estrogen deficiency-induced osteoporosis and proposes an integrated gut-metabolite-immune-bone framework. Rather than acting solely on bone cells, these interventions may reshape microbial metabolites, intestinal barrier function, estrogen availability, immune balance, and post-transcriptional regulation. This framework highlights priorities for causal multi-omics studies, microbiota-stratified trials, and the clinical evaluation of individualized nutrition-based interventions as potential adjunctive strategies. |
| Publish Date |
2026-11-10 01:43 |
| Citation |
Luo L, Zhang T, Xu WS. Natural bioactive compounds in estrogen deficiency-induced osteoporosis: Classification and an integrated gut microbiota-metabolite-immune-bone framework. World J Orthop 2026; 17(11): 127949
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| URL |
https://www.wjgnet.com/2218-5836/full/v17/i11/127949.htm |
| DOI |
https://doi.org/10.5312/wjo.127949 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
