Publication Name	World Journal of Translational Medicine
Manuscript ID	12796
Country	China

Received	2014-07-26 08:01
Peer-Review Started	2014-07-27 22:35
To Make the First Decision	2014-08-28 15:09
Return for Revision	2014-09-01 17:49
Revised	2014-09-14 13:52
Second Decision	2014-11-21 08:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-01 14:04
Articles in Press	2014-12-01 14:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-24 10:15
Publish the Manuscript Online	2015-04-14 17:36

ISSN	2220-6132 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Therapeutic targets in gastrointestinal stromal tumors
Manuscript Source	Invited Manuscript
All Author List	Jia-Qing Zhu and Wen-Bin Ou
Funding Agency and Grant Number	Funding Agency Grant Number Special Project of Zhejiang Province 2012C03007-4 Zhejiang Public Technology Research Program 2014C33234 Zhejiang Provincial Top Key Discipline of Biology, and Science Foundation of Zhejiang Sci-Tech University 14042107-Y
Corresponding Author	Dr. Wen-Bin Ou, College of Life Sciences, Zhejiang Sci-Tech University, 866 Yuhangtang Road, Hangzhou 310018, Zhejiang Province, China. ouwenbin@tsinghua.org.cn
Key Words	Gastrointestinal stromal tumors; Tyrosine kinase inhibitors; KIT; Platelet-derived growth factor receptor α; Targets
Core Tip	Oncogenic KIT and platelet-derived growth factor receptor α (PDGFRA) mutations are compelling therapeutic targets in gastrointestinal stromal tumors (GISTs), and the KIT/PDGFRA kinase inhibitors imatinib, sunitinib, and regorafenib are the standards of care for patients with unresectable or metastatic GIST. However, most patients eventually develop resistance to these kinase inhibitors, resulting in an urgent need to identify biologically rational targets for novel therapies. Herein, we review advances in the research on GIST and the therapies that are used to treat it. Additionally, we discuss novel agents, targets, and strategies for the future treatment of GIST.
Publish Date	2015-04-14 17:36
Citation	Zhu JQ, Ou WB. Therapeutic targets in gastrointestinal stromal tumors. World J Transl Med 2015; 4(1): 25-37
URL	http://www.wjgnet.com/2220-6132/full/v4/i1/25.htm
DOI	http://dx.doi.org/10.5528/wjtm.v4.i1.25

Full Article (PDF)	WJTM-4-25.pdf
Full Article (Word)	WJTM-4-25.doc
Manuscript File	12796-Review.doc
Answering Reviewers	12796-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	12796-Conflict of interest.pdf
Copyright License Agreement	12796-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	E998-0DF3-52BF-4712-4EC7.pdf
Peer-review Report	12796-Peer review(s).pdf
Scientific Misconduct Check	12796-CrossCheck.jpg
Scientific Editor Work List	12796-Scientific editor work list.pdf