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3/26/2015 3:19:00 PM | Browse: 577 | Download: 967
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Received |
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2014-07-29 08:45 |
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Peer-Review Started |
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2014-07-29 21:43 |
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To Make the First Decision |
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2014-10-14 17:57 |
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Return for Revision |
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2014-10-16 18:34 |
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Revised |
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2014-11-08 05:06 |
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Second Decision |
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2014-11-21 12:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-12-01 13:57 |
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Articles in Press |
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2014-12-01 13:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-02-07 09:24 |
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Publish the Manuscript Online |
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2015-03-20 10:47 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biology |
| Manuscript Type |
Review |
| Article Title |
Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ying Xiong, Lindsay T McDonald, Dayvia L Russell, Ryan R Kelly, Katie R Wilson, Meenal Mehrotra, Adam C Soloff and Amanda C LaRue |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| NIH/NCI |
R01 CA148772(to Amanda C LaRue) |
| Biomedical Laboratory Research and Development Program of the Department of Veterans Affairs (Merit Awards) |
to Amanda C LaRue |
| Hollings Cancer Center (Translational Research Pilot Project) |
P30 CA138313(to Amanda C LaRue) |
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| Corresponding Author |
Amanda C LaRue, PhD, Research Health Scientist and Associate Professor, Research Services, Ralph H Johnson Veterans Affairs Medical Center, 109 Bee Street, Charleston, SC 29403, United States. laruerc@musc.edu
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| Key Words |
Hematopoietic stem cell; Cancer associated adipocyte; Mesenchymal stromal cell; Tumor progression; Cancer associated fibroblast; Plasticity; Metastasis; Fibrocyte |
| Core Tip |
This review examines the roles of cancer-associated adipocytes (CAAs) and cancer-associated fibroblasts (CAFs) in remodeling of the tumor micro-environment (TME), presents evidence for a unique hematopoietic stem cell origin for both CAAs and CAFs, and discusses potential therapeutic implications of this novel origin. Studies highlighted herein emphasize the necessity of developing an understanding of the origins of cells in the TME and the importance of multipronged therapeutic targets directed at preventing both the incorporation and effects of stromal remodeling by the cells of the TME.
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| Publish Date |
2015-03-20 10:47 |
| Citation |
Xiong Y, McDonald LT, Russell DL, Kelly RR, Wilson KR, Mehrotra M, Soloff AC, LaRue AC. Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment. World J Stem Cells 2015; 7(2): 253-265 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i2/253.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i2.253 |
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