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2/5/2015 4:50:00 PM | Browse: 743 | Download: 1451
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Received |
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2014-07-29 10:01 |
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Peer-Review Started |
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2014-07-29 17:40 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-09-18 13:44 |
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Revised |
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2014-10-03 00:45 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-11-12 13:58 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-11-19 11:16 |
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Articles in Press |
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2014-11-19 11:17 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-22 10:23 |
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Publish the Manuscript Online |
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2015-02-05 16:28 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Review |
| Article Title |
Review and update on the molecular basis of Leber congenital amaurosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Oscar Francisco Chacon-Camacho and Juan Carlos Zenteno |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Juan Carlos Zenteno, Genetics Department-Research Unit, Institute of Ophthalmology, "Conde de Valenciana", Chimalpopoca #14, Col. Obrera, Cuauhtemoc, Mexico City 06800,
Mexico. jczenteno@institutodeoftalmologia.org
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| Key Words |
Gene therapy; Leber congenital amaurosis; Retinal dystrophies; Childhood blindness |
| Core Tip |
Leber congenital amaurosis (LCA) is the most severe retinal dystrophy causing blindness before the age of 1 year. Clinical ophthalmological findings together with electroretinogram study, OCT imaging and retinal molecular-genetic technologies provide a precise diagnosis in these individuals. Gene-specific phenotypic features exist in LCA, and in this way is possible to predict the underlying genetic defect in some patients on the basis of ophthalmological clues. Clinical, molecular-genetics, phenotype-genotype and gene therapy aspects of LCA are described. |
| Publish Date |
2015-02-05 16:28 |
| Citation |
Chacon-Camacho OF, Zenteno JC. Review and update on the molecular basis of Leber congenital amaurosis. World J Clin Cases 2015; 3(2): 112-124 |
| URL |
http://www.wjgnet.com/2307-8960/full/v3/i2/112.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v3.i2.112 |
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