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1/14/2015 3:35:00 PM | Browse: 521 | Download: 1136
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Received |
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2014-07-31 08:30 |
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Peer-Review Started |
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2014-07-31 15:59 |
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To Make the First Decision |
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2014-09-28 13:58 |
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Return for Revision |
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2014-09-29 19:05 |
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Revised |
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2014-10-14 13:11 |
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Second Decision |
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2014-11-03 17:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2014-11-03 17:18 |
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Articles in Press |
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2014-11-03 17:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-12-25 14:25 |
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Publish the Manuscript Online |
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2015-01-14 11:53 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Fetal vs adult mesenchymal stem cells achieve greater gene expression, but less osteoinduction
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Juan E Santiago-Torres, Rebecca Lovasz and Alicia L Bertone |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ohio State University College of Medicine Roessler Research Scholarship (In part) |
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| National Cancer Institution of the United States grant |
P30 CA016058(In part) |
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| Corresponding Author |
Alicia L Bertone, DVM, PhD, Professor, Comparative Orthopedic Research Laboratory, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Tharp St, Columbus, OH 43210, United States. bertone.1@osu.edu |
| Key Words |
Adenovirus; Bone morphogenic protein 2; Fetal; Green fluorescent protein; Mesenchymal stem cell; Gene transfer technique |
| Core Tip |
Fetal mesenchymal stem cells (MSCs) can be genetically manipulated ex vivo with adenoviral vectors without major effects on stemness. Their greater expression of exogenous genes than adult MSCs is promising for MSC-mediated gene therapy. MSC-mediated bone morphogenic protein 2 gene delivery provides osteogenic induction in vivo, which could have clinical applications in bone regeneration. Nonetheless, the abbreviated expression of the exogenous gene provided via adenoviral transduction may limit their applications in vivo. |
| Publish Date |
2015-01-14 11:53 |
| Citation |
Santiago-Torres JE, Lovasz R, Bertone AL. Fetal vs adult mesenchymal stem cells achieve greater gene expression, but less osteoinduction. World J Stem Cells 2015; 7(1): 223-234 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i1/223.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i1.223 |
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