Publication Name	World Journal of Translational Medicine
Manuscript ID	13166
Country	Italy

Received	2014-08-08 19:16
Peer-Review Started	2014-08-09 13:24
To Make the First Decision	2014-10-14 18:11
Return for Revision	2014-10-20 12:34
Revised	2014-11-10 19:34
Second Decision	2015-03-11 13:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-03-20 10:19
Articles in Press	2015-03-20 10:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-26 10:22
Publish the Manuscript Online	2015-04-14 17:36

ISSN	2220-6132 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Epigenetics and DNA methylation in cancer
Manuscript Source	Invited Manuscript
All Author List	Laura Lattanzio and Cristiana Lo Nigro
Funding Agency and Grant Number
Corresponding Author	Cristiana Lo Nigro, PhD, Laboratory Cancer Genetics and Translational Oncology, Medical Oncology, S. Croce University Hospital, Via Carle 25, 12100 Cuneo, Italy. lonigro.c@ospedale.cuneo.it
Key Words	Epigenetics; DNA methylation; Cancer; Regulation of transcription; Prognostic markers
Core Tip	Carcinogenesis occurs through a combination of mutational and epimutational alterations involving key pathways in cellular growth and division. Tumour cells exhibit two main differences from normal cells in DNA methylation: a global reduction in DNA methylation and the hypermethylation of specific sequences, mainly CpG islands, that cause the transcriptional silencing of tumour suppressor genes, thus directly driving the carcinogenic. In this review, we’ll focus on our current understanding of this process, aiming to discuss how the analysis of cancer methylomes and the re-expression of epigenetically silenced genes have potential uses in developing more effective cancer therapies.
Publish Date	2015-04-14 17:36
Citation	Lattanzio L, Lo Nigro C. Epigenetics and DNA methylation in cancer. World J Transl Med 2015; 4(1): 11-24
URL	http://www.wjgnet.com/2220-6132/full/v4/i1/11.htm
DOI	http://dx.doi.org/10.5528/wjtm.v4.i1.11

Full Article (PDF)	WJTM-4-11.pdf
Full Article (Word)	WJTM-4-11.doc
Manuscript File	13166-Review.doc
Answering Reviewers	13166-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13166-Conflict-of-interest statement.pdf
Copyright License Agreement	13166-Copyright assignment.pdf
Peer-review Report	13166-Peer-review(s).pdf
Scientific Misconduct Check	13166-Scientific misconduct check.pdf
Scientific Editor Work List	13166-Scientific editor work list.pdf