Publication Name	World Journal of Critical Care Medicine
Manuscript ID	13591
Country

Received	2014-08-28 09:03
Peer-Review Started	2014-08-31 21:09
To Make the First Decision	2014-10-14 17:51
Return for Revision	2014-10-17 10:50
Revised	2014-10-21 00:19
Second Decision	2014-11-12 14:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-19 11:30
Articles in Press	2014-11-19 11:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-05 17:50
Publish the Manuscript Online	2015-02-11 18:50

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Critical Care Medicine
Manuscript Type	Systematic Reviews
Article Title	Thoracic epidural anesthesia: Effects on splanchnic circulation and implications in Anesthesia and Intensive care
Manuscript Source	Invited Manuscript
All Author List	Antonio Siniscalchi, Lorenzo Gamberini, Cristiana Laici, Tommaso Bardi and Stefano Faenza
Funding Agency and Grant Number
Corresponding Author	Antonio Siniscalchi, MD, Division of Anesthesiology, Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. sinianest@libero.it
Key Words	Liver function tests; Pancreatitis; Microcirculation; Intestine; Splanc­hnic; Circulation; Epidural; Anesthesia
Core Tip	Effects of thoracic epidural anesthesia on splanchnic circulation are still poorly understood. The influence on macro-hemodynamics seems to vary based on the metameric extension of the blockade, the volume repletion and the hemodynamic status of the patient. Thus epidural anesthesia could reduce regional blood flow to splanchnic organs and have detrimental effects on oxygen delivery. However, there is increasing evidence, in particular deriving from animal studies, of a possible protective effect on microcirculation of the epidural blockade, especially in low flow states. In fact, despite reducing perfusion pressure, thoracic epidural anesthesia could foster perfusion of microcirculatory weak units and reduce local dysoxia.
Publish Date	2015-02-11 18:50
Citation	Siniscalchi A, Gamberini L, Laici C, Bardi T, Faenza S. Thoracic epidural anesthesia: Effects on splanchnic circulation and implications in Anesthesia and Intensive care. World J Crit Care Med 2015; 4(1): 89-104
URL	http://www.wjgnet.com/2220-3141/full/v4/i1/89.htm
DOI	http://dx.doi.org/10.5492/wjccm.v4.i1.89

Full Article (PDF)	WJCCM-4-89.pdf
Full Article (Word)	WJCCM-4-89.doc
Manuscript File	13591-Review.doc
Answering Reviewers	13591-Answering reviewers.pdf
Copyright License Agreement	13591-Copyright assignment.pdf
Peer-review Report	13591-Peer review(s).pdf
Scientific Misconduct Check	13591-CrossCheck.jpg
Scientific Editor Work List	13591-Scientific editor work list.pdf