Publication Name	World Journal of Hepatology
Manuscript ID	13641
Country	Taiwan

Received	2014-08-28 17:54
Peer-Review Started	2014-08-28 19:00
To Make the First Decision	2014-12-17 11:38
Return for Revision	2014-12-19 10:49
Revised	2014-12-22 12:31
Second Decision	2015-03-16 17:45
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-02 16:06
Articles in Press	2015-04-02 16:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-15 10:02
Publish the Manuscript Online	2015-06-03 12:00

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Review
Article Title	Hepatitis C virus: Virology, diagnosis and treatment
Manuscript Source	Invited Manuscript
All Author List	Hui-Chun Li and Shih-Yen Lo
Funding Agency and Grant Number	Funding Agency Grant Number National Science Council of Taiwan NSC 101-2320-B-320-011-MY3 (Dr. Shih-Yen Lo) Tzu Chi University TCIRP 103002-03 (to Dr. Shih-Yen Lo) Tzu Chi University TCIRP 103002-02 (to Dr. Hui-Chun Li)
Corresponding Author	Dr. Shih-Yen Lo, Department of Laboratory Medicine and Biotechnology, Tzu Chi University, 701, Section 3, Chung Yang Road, Hualien 97004, Taiwan. losylo@mail.tcu.edu.tw
Key Words	Hepatitis C virus; Diagnosis; Treatment; Hepatocellular carcinoma; Nucleic acid test; Enzyme immunoassay; Interferon; Direct acting antivirals; Host-targeted agents; Sofosbuvir
Core Tip	Understanding the general properties of hepatitis C virus (HCV) viral RNA and proteins facilitates the development of sensitive diagnostic tools and effective antiviral treatments. At present, serologic screening test is recommended to perform on individuals in the high risk groups and nucleic acid tests are re-commended to confirm the active HCV infections. To 2014, in addition to pegylated interferon and ribavirin, boceprevir, telaprevir, simeprevir, sofosbuvir and Harvoni are approved by Food and Drug Administration to treat HCV infections. The majority of HCV infections can be cured by these anti-viral treatments. An efficient prophylactic vaccine will be the next challenge in the fight against HCV infection.
Publish Date	2015-06-03 12:00
Citation	Li HC, Lo SY. Hepatitis C virus: Virology, diagnosis and treatment. World J Hepatol 2015; 7(10): 1377-1389
URL	http://www.wjgnet.com/1948-5182/full/v7/i10/1377.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i10.1377

Full Article (PDF)	WJH-7-1377.pdf
Full Article (Word)	WJH-7-1377.doc
Manuscript File	13641-Review.docx
Answering Reviewers	13641-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13641-Conflict-of-interest statement.pdf
Copyright License Agreement	13641-Copyright assignment.pdf
Peer-review Report	13641-Peer-review(s).pdf
Scientific Misconduct Check	13641-Scientific misconduct check.pdf
Scientific Editor Work List	13641-Scientific editor work list.pdf