Publication Name	World Journal of Gastroenterology
Manuscript ID	14137
Country	China

Received	2014-09-21 08:49
Peer-Review Started	2014-09-21 09:00
First Decision by Editorial Office Director
Return for Revision	2014-10-19 16:00
Revised
Publication Fee Transferred
Second Decision by Editor	2014-11-25 18:03
Second Decision by Editor-in-Chief	2014-11-25 23:37
Final Decision by Editorial Office Director	2014-12-08 16:15
Articles in Press	2014-12-08 17:13
Edit the Manuscript by Language Editor	2014-12-29 08:01
Typeset the Manuscript	2015-02-26 16:17
Publish the Manuscript Online	2015-03-09 15:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effect of bifidobacterium on defensin-5 expression in intestinal injury of preweaning rats
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Wang, Shu-Fen Yang, Li-Hong Ren, Xiu-Xiu Zhang and Shui-Lian Yu
Funding Agency and Grant Number	Funding Agency Grant Number Foundation of Education Department of Heilongjiang Province 11521124
Corresponding Author	Wei Wang, MD, Department of Pediatrics, the Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Nangang District, Harbin 150086, Heilongjiang Province, China. wendywang_1972@126.com
Key Words	Bifidobacterium; Lipopolysaccharide; Ileum; Myeloperoxidase; Defensin-5
Core Tip	This study investigated the serum and ileal contents of myeloperoxidase (MPO) and the expression of ileal Defensin-5 mRNA in the preweaning rats with lipopolysaccharide (LPS)-induced intestinal injury. Serum and ileal MPO contents in the model group (group E) were significantly higher than those in the control group (group C) (P < 0.05), which peaked at 12 h and 6 h, respectively. MPO contents in the treatment group (group T) were significantly lower than those in group E (P < 0.05). The expression of defensin-5 mRNA in group E was significantly up-regulated, peaked at 2 h, and then decreased gradually. The expression of defensin-5 mRNA in group T was significantly lower than that in group E (P < 0.05). Serum and ileal MPO contents and ileal expression of defensin-5 mRNA increased in preweaning rats with LPS-induced intestinal injury. Bifidobacterium protects the gut by inhibiting MPO activity, not by increasing defensin-5 secretion.
Publish Date	2015-03-09 15:58
Citation	Wang W, Yang SF, Ren LH, Zhang XX, Yu SL. Effect of bifidobacterium on defensin-5 expression in intestinal injury of preweaning rats. World J Gastroenterol 2015; 21(9): 2638-2644
URL	http://www.wjgnet.com/1007-9327/full/v21/i9/2638.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i9.2638

Full Article (PDF)	WJG-21-2638.pdf
Full Article (Word)	WJG-21-2638.doc
Manuscript File	14137-Review.doc
Answering Reviewers	14137-Answering reviewers.pdf
Copyright License Agreement	14137-Copyright assignment.pdf
Peer-review Report	14137-Peer review(s).pdf
Scientific Misconduct Check	14137-CrossCheck.jpg
Scientific Editor Work List	14137-Scientific editor work list.pdf