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1/20/2015 1:07:00 PM | Browse: 385 | Download: 937
Publication Name World Journal of Dermatology
Manuscript ID 14147
Country of Manuscript Source United Kingdom
Received
2014-09-22 09:39
Peer-Review Started
2014-09-22 16:38
To Make the First Decision
2014-10-28 14:25
Return for Revision
2014-11-01 18:19
Revised
2014-11-29 17:26
Second Decision
2014-12-11 17:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-12-17 16:13
Articles in Press
2014-12-17 16:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-01-16 13:49
Publish the Manuscript Online
2015-01-20 11:05
ISSN 2218-6190 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Dermatology
Manuscript Type Review
Article Title From the outside-in: Epidermal targeting as a paradigm for atopic disease therapy
Manuscript Source Invited Manuscript
All Author List Rachel MC Gillespie and Sara J Brown
Funding Agency and Grant Number
Corresponding author Sara J Brown, MD, Dermatology and Genetic Medicine, College of Medicine, Dentistry and Nursing, University of Dundee, James Arrott Drive, Ninewells Hospital and Medical School, DD1 9SYD undee, United Kingdom. s.j.brown@dundee.ac.uk
Keywords Atopic dermatitis; Eczema; Filaggrin; Skin barrier; Kallikrein; Thymic stromal lymphopoietin; Allergic sensitization; Atopic march
Core Tip Atopic diseases [including atopic dermatitis (AD), allergic rhinitis and asthma] are characterised by Th2-type inflammation. Research over the past decade has highlighted a crucial role for primary skin barrier impairment in the pathogenesis of AD and associated atopic phenotypes. Notably, the epidermal protein, filaggrin, epidermal serine proteases, and the pro-Th2 cytokine thymic stromal lymphopoietin, have been implicated in disease development. We review the evidence upholding a role for epidermal defects in the initiation of skin inflammation in AD, allergic sensitization and pathogenesis of the “atopic march”, and discuss the clinical implications of these findings.
Publish Date 2015-01-20 11:05
Citation Gillespie RMC, Brown SJ. From the outside-in: Epidermal targeting as a paradigm for atopic disease therapy. World J Dermatol 2015; 4(1): 16-32
Url http://www.wjgnet.com/2218-6190/full/v4/i1/16.htm
DOI http://dx.doi.org/10.5314/wjd.v4.i1.16
Full Article (PDF) WJD-4-1.pdf
Full Article (Word) WJD-4-1.doc
Manuscript File 14147-Review.docx
Answering Reviewers 14147-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 14147-Conflict-of-interest statement.pdf
Copyright License Agreement 14147-Copyright assignment.pdf
Peer-review Report 14147-Peer review(s).pdf
Scientific Editor Work List 14147-Scientific editor work list.pdf