Publication Name	World Journal of Cardiology
Manuscript ID	14833
Country	Germany

Received	2014-10-27 08:06
Peer-Review Started	2014-10-27 10:14
To Make the First Decision	2014-11-27 12:09
Return for Revision	2014-12-03 12:04
Revised	2014-12-10 00:00
Second Decision	2014-12-26 08:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-31 13:42
Articles in Press	2014-12-31 13:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-12 13:30
Publish the Manuscript Online	2015-01-21 17:04

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Editorial
Article Title	Opportunities and challenges of clinical trials in cardiology using composite primary endpoints
Manuscript Source	Invited Manuscript
All Author List	Geraldine Rauch, Bernhard Rauch, Svenja Schüler and Meinhard Kieser
Funding Agency and Grant Number
Corresponding Author	Dr. Geraldine Rauch, Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany. rauch@imbi.uni-heidelberg.de
Key Words	Composite endpoint; Competing risks; Multiple testing; Time-to-event; Adaptive designs
Core Tip	When planning a clinical trial with a composite primary endpoint: (1) Be aware of planning uncertainties when calculating the sample size and incorporate them in an adequate way; (2) Include a multiple testing strategy for an improved interpretation of the study results; (3) Take into account competing risks when analyzing the individual components of a composite endpoint; and (4) Analyze subsequent events in an adequate multi-stage model.
Publish Date	2015-01-21 17:04
Citation	Rauch G, Rauch B, Schüler S, Kieser M. Opportunities and challenges of clinical trials in cardiology using composite primary endpoints. World J Cardiol 2015; 7(1): 1-5
URL	http://www.wjgnet.com/1949-8462/full/v7/i1/1.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i1.1

Manuscript File	14833-Review.docx
Answering Reviewers	14833-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14833-Conflict-of-interest statement.pdf
Copyright License Agreement	14833-Copyright assignment.pdf
Peer-review Report	14833-Peer review(s).pdf
Scientific Misconduct Check	14833-CrossCheck.jpg
Scientific Editor Work List	14833-Scientific editor work list.pdf