Publication Name	World Journal of Gastroenterology
Manuscript ID	15349
Country	Germany

Received	2014-11-23 13:25
Peer-Review Started	2014-11-23 19:01
To Make the First Decision	2015-01-08 16:51
Return for Revision	2015-01-16 10:33
Revised	2015-01-22 01:04
Second Decision	2015-02-10 21:26
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-11 15:51
Articles in Press	2015-02-11 16:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-14 18:26
Typeset the Manuscript	2015-04-03 10:16
Publish the Manuscript Online	2015-04-20 15:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders
Manuscript Source	Invited Manuscript
All Author List	Rolf Teschke, Albrecht Wolff, Christian Frenzel, Axel Eickhoff and Johannes Schulze
Funding Agency and Grant Number
Corresponding Author	Rolf Teschke, MD, Professor of Medicine, Department of Internal Medicine II, Klinikum Hanau, Academic Teaching Hospital of the Goethe University of Frankfurt/Main, Leimenstrasse 20, D-63450 Hanau, Germany. rolf.teschke@gmx.de
Key Words	Evidence based trials; Traditional Chinese medicine; Herbal traditional Chinese Medicine; Gastrointestinal disorders
Core Tip	This review focuses on evidence based trials of herbal traditional Chinese Medicine (TCM) in managing gastrointestinal disorders and presents a practical reference guide on its role for treating these diseases. Overall quality of placebo controlled, randomized, controlled, double blind clinical trials was poor; mostly neglecting stringent evidence based diagnostic and therapeutic criteria. Accordingly, appropriate Cochrane reviews and metaanalyses were limited and failed to support valid, clinically relevant evidence based efficiency of herbal TCM in most gastrointestinal diseases, including gastroesophageal reflux disease, gastric or duodenal ulcer, dyspepsia, irritable bowel syndrome, ulcerative colitis, and Crohn's disease. Despite its interesting philosophical background with a long history, the general use of herbal TCM to treat various gastrointestinal diseases cannot be recommended due to lacking evidence based efficiency and a negative risk/benefit profile. Thus, substantial skepticism remains, proposing future studies with focus on well performed placebo controlled, randomized, double blind clinical trials, considering also herbal product quality and standard criteria of diagnosis, treatment, and outcome.
Publish Date	2015-04-20 15:10
Citation	Teschke R, Wolff A, Frenzel C, Eickhoff A, Schulze J. Herbal traditional Chinese medicine and its evidence base in gastrointestinal disorders. World J Gastroenterol 2015; 21(15): 4466-4490
URL	http://www.wjgnet.com/1007-9327/full/v21/i15/4466.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i15.4466

Full Article (PDF)	WJG-21-4466.pdf
Full Article (Word)	WJG-21-4466.doc
Manuscript File	15349-Review.doc
Answering Reviewers	15349-Answering reviewers.pdf
Copyright License Agreement	15349-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15349-Language certificate.pdf
Peer-review Report	15349-Peer-review(s).pdf
Scientific Misconduct Check	15349-Scientific misconduct check.pdf
Scientific Editor Work List	15349-Scientific editor work list.pdf