Publication Name	World Journal of Critical Care Medicine
Manuscript ID	15421
Country

Received	2014-11-26 09:09
Peer-Review Started	2014-11-26 16:58
To Make the First Decision	2014-12-12 17:34
Return for Revision	2014-12-18 14:45
Revised	2015-01-10 00:25
Second Decision	2015-04-01 14:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-09 16:47
Articles in Press	2015-04-09 16:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-27 17:14
Publish the Manuscript Online	2015-08-17 18:00

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Respiratory System
Manuscript Type	Review
Article Title	Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function
Manuscript Source	Invited Manuscript
All Author List	Emer P Reeves, Cormac McCarthy, Oliver J McElvaney, Maya Sakthi N Vijayan, Michelle M White, Danielle M Dunlea, Kerstin Pohl, Noreen Lacey and Noel G McElvaney
Funding Agency and Grant Number
Corresponding Author	Dr. Emer P Reeves, PhD, MSc, Respira­tory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland. emerreeves@rcsi.ie
Key Words	Cystic fibrosis; Hypertonic saline; Mucociliary clearance; Neutrophils and inflammation
Core Tip	The pathogenesis of lung disease in cystic fibrosis (CF) is characterised by decreased airway surface liquid volume and subsequent failure of normal mucociliary clearance. Therapies acting against airway mucus in CF include aerosolized hypertonic saline (HTS). It has been shown that HTS aids mucociliary clearance by restoring the liquid layer lining the airways. However, recent studies are beginning to broaden our view on the beneficial effects of HTS, which now extend to include anti-inflammatory properties. This review aims to discuss the therapeutic benefits of HTS and to identify the potential benefits of aerosolized HTS for attenuation of neutrophil function.
Publish Date	2015-08-17 18:00
Citation	Reeves EP, McCarthy C, McElvaney OJ, Vijayan MSN, White MM, Dunlea DM, Pohl K, Lacey N, McElvaney NG. Inhaled hypertonic saline for cystic fibrosis: Reviewing the potential evidence for modulation of neutrophil signalling and function. World J Crit Care Med 2015; 4(3): 179-191
URL	http://www.wjgnet.com/2220-3141/full/v4/i3/179.htm
DOI	http://dx.doi.org/10.5492/wjccm.v4.i3.179

Full Article (PDF)	WJCCM-4-179.pdf
Full Article (Word)	WJCCM-4-179.doc
Manuscript File	15421-Review.docx
Answering Reviewers	15421-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15421-Conflict-of-interest statement.pdf
Copyright License Agreement	15421-Copyright assignment.pdf
Peer-review Report	15421-Peer-review(s).pdf
Scientific Misconduct Check	15421-Scientific misconduct check.pdf
Scientific Editor Work List	15421-Scientific editor work list.pdf