Publication Name	World Journal of Gastroenterology
Manuscript ID	15582
Country	Romania

Received	2014-11-29 13:07
Peer-Review Started	2014-11-29 22:48
To Make the First Decision	2014-12-26 13:22
Return for Revision	2014-12-31 09:18
Revised	2015-01-17 06:12
Second Decision	2015-02-11 23:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-02-13 10:39
Articles in Press	2015-02-13 11:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-04 10:09
Typeset the Manuscript	2015-03-26 16:09
Publish the Manuscript Online	2015-04-15 11:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question
Manuscript Source	Invited Manuscript
All Author List	Letiția Adela Maria Streba, Cristin Constantin Vere, Ion Rogoveanu and Costin Teodor Streba
Funding Agency and Grant Number	Funding Agency Grant Number European Social Found, Human Resources Development Operational Programme 2007-2013 POSDRU/159/1.5/133377
Corresponding Author	Costin Teodor Streba, MD, PhD, MSc, Research Center of Gastroenterology and Hepatology of Craiova, University of Medicine and Pharmacyof Craiova, 1 Mai 66, 200639 Craiova, Romania. costinstreba@gmail.com
Key Words	Diabetes mellitus; Hepatocellular carcinoma; Metabolic syndrome; Non-alcoholic fatty liver disease; Obesity
Core Tip	Nonalcoholic liver disease (NAFLD) comprises both simple steatosis or nonalcoholic fatty liver and nonalcoholic steatohepatitis, with or without cirrhosis. Recent data demonstrate a strong association between most features of metabolic syndrome and NAFLD. Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, for which current epidemiologic data show an increased incidence in NAFLD patients. Basic research has identified pathways linking obesity, type 2 diabetes, systemic inflammation, NAFLD/nonalcoholic steatohepatitis, and HCC. However, more data are necessary in order to effectively establish these relationships, and perhaps pave the way for possible cures to prevent HCC in certain populations.
Publish Date	2015-04-15 11:01
Citation	Streba LAM, Vere CC, Rogoveanu I, Streba CT. Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question. World J Gastroenterol 2015; 21(14): 4103-4110
URL	http://www.wjgnet.com/1007-9327/full/v21/i14/4103.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i14.4103

Full Article (PDF)	WJG-21-4103.pdf
Full Article (Word)	WJG-21-4103.doc
Manuscript File	15582-Review.doc
Answering Reviewers	15582-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15582-Conflicts-of-interest statement.pdf
Copyright License Agreement	15582-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	15582-Language certificate.pdf
Peer-review Report	15582-Peer-review(s).pdf
Scientific Misconduct Check	15582-Scientific misconduct check.pdf
Scientific Editor Work List	15582-Scientific editor work list.pdf