Publication Name	World Journal of Anesthesiology
Manuscript ID	15784
Country	Japan

Received	2014-12-09 08:56
Peer-Review Started	2014-12-09 10:28
To Make the First Decision	2014-12-26 13:03
Return for Revision	2014-12-31 10:42
Revised	2015-01-05 00:00
Second Decision	2015-01-08 17:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-01-19 13:44
Articles in Press	2015-01-19 13:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-23 17:21
Publish the Manuscript Online	2015-03-31 13:43

ISSN	2218-6182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Editorial
Article Title	Benzodiazepine in spinally mediated analgesia
Manuscript Source	Invited Manuscript
All Author List	Tomoki Nishiyama
Funding Agency and Grant Number
Corresponding Author	Tomoki Nishiyama, MD, PhD, Department of Anesthesiology, Shinagawa Shishokai Hospital, 1-29-7, Kita-Shinagawa, Shinagawa, Tokyo 140-0001, Japan. nishit-tky@umin.ac.jp
Key Words	Spinal cord; Analgesia; Benzodiazepine; Neurotoxicity; Intrathecal; Epidural
Core Tip	Intrathecal or epidural midazolam has analgesic effect acting on benzodiazepine/γ-amino butyric acid receptor in the spinal cord. Many clinical and animal studies showed no harmful side effects, while in some animal experiments, neurotoxicity was found. Therefore, we need further evidence to bring it into clinical application.
Publish Date	2015-03-31 13:43
Citation	Nishiyama T. Benzodiazepine in spinally mediated analgesia. World J Anesthesiol 2015; 4(1): 5-9
URL	http://www.wjgnet.com/2218-6182/full/v4/i1/5.htm
DOI	http://dx.doi.org/10.5313/wja.v4.i1.5

Manuscript File	15784-Review.doc
Answering Reviewers	15784-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	15784-Conflict-of-interest statement.pdf
Copyright License Agreement	15784-Copyright assignment.pdf
Peer-review Report	15784-Peer review(s).pdf
Scientific Misconduct Check	15784-CrossCheck.jpg
Scientific Editor Work List	15784-Scientific editor work list.pdf